Sarcoidosis during infliximab therapy for Crohn's disease

被引：21

作者：

Takahashi, Hidetoshi ^{[1
]}

Kaneta, Kazuhiro ^{[1
]}

Honma, Masaru ^{[1
]}

Ishida-Yamamoto, Akemi ^{[1
]}

Ashida, Tomonori ^{[2
]}

Kohgo, Yutaka ^{[2
]}

Ohsaki, Yoshinobu ^{[3
]}

Iizuka, Hajime ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Dermatol, Asahikawa, Hokkaido 0788510, Japan

[2] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 0788510, Japan

[3] Asahikawa Med Coll, Dept Internal Med 1, Asahikawa, Hokkaido 0788510, Japan

来源：

JOURNAL OF DERMATOLOGY | 2010年 / 37卷 / 05期

关键词：

infliximab; psoriasiform eruption; tumor necrosis factor-alpha; TUMOR-NECROSIS-FACTOR; PULMONARY SARCOIDOSIS; ETANERCEPT THERAPY; ARTHRITIS; PATIENT;

D O I：

10.1111/j.1346-8138.2010.00861.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) antagonists are effective for inflammatory diseases, such as Crohn's disease, rheumatoid arthritis (RA) and psoriasis. Although TNF-alpha antagonists are also useful for sarcoidosis, paradoxical occurrence of sarcoidosis or sarcoidal reaction may be observed. We report a Crohn's disease patient, who developed sarcoidosis during infliximab therapy. A 35-year-old man had been receiving infliximab for 7 months for Crohn's disease. He developed cough and fever, accompanied by an infiltrated erythematous plaque on his right knee. The chest radiography, skin biopsy and laboratory findings were all consistent with sarcoidosis.

引用

页码：471 / 474

页数：4

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