Iron-Catalyzed Allylic Amination Directly from Allylic Alcohols

被引：103
作者：
Emayavaramban, Balakumar [1 ]
Roy, Moumita [1 ]
Sundararaju, Basker [1 ]
机构：
[1] Indian Inst Technol, Fine Chem Lab, Dept Chem, Kanpur 208016, Uttar Pradesh, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 12期
关键词：
alcohols; allylic compounds; amination; hydrogen borrowing; iron; METAL-DIENE COMPLEXES; MEDIATED 2+2+1 CYCLOADDITIONS; LIGAND-EXCHANGE REACTION; TRANSITION-METAL; ORGANIC-SYNTHESIS; BORROWING HYDROGEN; DIRECT ALKYLATION; CARBON-MONOXIDE; BOND FORMATION; SUBSTITUTION;
D O I：
10.1002/chem.201505214
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one-step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.
引用
收藏
页码：3952 / 3955
页数：4
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