N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

被引：83

作者：

Hu, Bin-bin ^{[1
]}

Wang, Xiao-yan ^{[2
]}

Gu, Xu-Yu ^{[1
]}

Zou, Chen ^{[1
]}

Gao, Zhen-jun ^{[3
]}

Zhang, Heng ^{[4
]}

Fan, Yu ^{[1
]}

机构：

[1] Jiangsu Univ, Affiliated Peoples Hosp, Canc Inst, Zhenjiang, Jiangsu, Peoples R China

[2] Jiangsu Prov Hosp, Sugian Branch Hosp, Digest Dept, Sugian, Jiangsu, Peoples R China

[3] Fudan Univ, Affiliated Zhongshan Hosp, Qingpu Branch Hosp, Digest Dept, Shanghai, Peoples R China

[4] Southeast Univ, Zhongda Hosp, Lishui Branch, Dept Gen Surg,Nanjing Lishui Dist Peoples Hosp, Nanjing, Jiangsu, Peoples R China

来源：

MOLECULAR CANCER | 2019年 / 18卷 / 01期

关键词：

MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; MYELOID-LEUKEMIA; METTL3; PROMOTES; GASTRIC-CANCER; NUCLEAR-RNA; EXPRESSION; PROLIFERATION; METHYLATION; N6-METHYLADENOSINE;

D O I：

10.1186/s12943-019-1099-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m(6)A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m(6)A in gastrointestinal tract cancers.

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