Revealing Genomic Footprints of Selection for Fiber and Production Traits in Three Indian Sheep Breeds

被引：22

作者：

Rajawat, Divya ^{[1
]}

Panigrahi, Manjit ^{[1
]}

Kumar, Harshit ^{[1
]}

Nayak, Sonali Sonejita ^{[1
]}

Saravanan, K. A. ^{[1
]}

Bhushan, Bharat ^{[1
]}

Dutt, Triveni ^{[2
]}

机构：

[1] Indian Vet Res Inst, Div Anim Genet, Bareilly, Uttar Pradesh, India

[2] Indian Vet Res Inst, Livestock Prod & Management Sect, Bareilly, Uttar Pradesh, India

来源：

JOURNAL OF NATURAL FIBERS | 2022年 / 19卷 / 16期

关键词：

Composite likelihood ratio; genomic footprints; selective sweep; sheep; Tajima's D; POSITIVE SELECTION; CANDIDATE GENES; SIGNATURES; RECEPTOR; DOMESTICATION; ASSOCIATION; SEASONALITY; MUTATION; SWEEPS; MODEL;

D O I：

10.1080/15440478.2022.2069198

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

The present broad range of sheep phenotypic variation is the consequence of selection for various production characteristics such as wool, milk, meat, and natural adaptability to diverse situations. In the current study, the genomic data of 79 animals from three Indian sheep breeds (Changthangi, Deccani, and Garole) were explored to decipher regions under positive selection for various productive traits using various statistical tools. We found 61, 102 regions using Tajima's D, CLR and 58, 38, and 71 regions using F-ST, FLK, and hapFLK, respectively, under selective sweep. Significant candidate genes related to various important traits, such as KLHL for fibre diameter and the OMA1 gene for feed-induced thermogenesis in Changthangi, were identified. In addition, the SYCP2 and NAPAS3 genes were found to be associated with seasonal reproductivity, and BMPR1B for fertilization capacity in Garole. In a previous study, the HSPA6 gene (Garole) was found to be associated with thermo-tolerance in the Angus sheep breed. The outcomes discussed here provide a basis for detecting selective sweeps that underlie genetic variations of traits that have functional importance.

引用

页码：14963 / 14974

页数：12

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