Convergent Three-Component Tetrazole Synthesis

被引：39

作者：

Chandgude, Ajay L. ^{[1
]}

Domling, Alexander ^{[1
]}

机构：

[1] Univ Groningen, Dept Drug Design, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 14期

基金：

美国国家卫生研究院;

关键词：

Multicomponent reactions; Microwave chemistry; Azides; Fused-ring systems; Nitrogen heterocycles; CARBOXYLIC-ACID ISOSTERES; SODIUM AZIDE SYSTEM; CHEMISTRY; DERIVATIVES; INHIBITION; DISCOVERY; ROUTES; AMIDE; MILD;

D O I：

10.1002/ejoc.201600317

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-accelerated, simple, and efficient method for the construction of the 1,5-tetrazole scaffold was developed. It comprises a multicomponent reaction of an amine, a carboxylic acid derivative, and an azide source. On the basis of the availability of the archetypical starting materials, this method provided very versatile synthetic access to 1,5-disubstituted tetrazoles. The usefulness of this method was demonstrated in the synthesis of biologically important fused tetrazole scaffolds and the marketed drug cilostazol.

引用

页码：2383 / 2387

页数：5

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