Investigation of dual plasmonic core-shell Ag@CuS nanoparticles for potential surface-enhanced Raman spectroscopy-guided photothermal therapy

被引:9
作者
Das, Anindita [1 ]
Arunagiri, Vinothini [2 ]
Tsai, Hsieh-Chih [2 ,3 ,4 ]
Prasannan, Adhimoorthy [5 ]
Lai, Juin-Yih [2 ,3 ,4 ]
Da-Hong, Po [5 ]
Moirangthem, Rakesh S. [1 ]
机构
[1] Indian Inst Technol, Indian Sch Mines, Nanophoton Lab, Dept Phys, Dhanbad 826004, Bihar, India
[2] Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan
[3] Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan
[4] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Taoyuan 320, Taiwan
[5] Natl Taiwan Univ Sci & Technol, Dept Mat Sci & Engn, Taipei 106, Taiwan
关键词
Ag@CuS metal-semiconductor nanocomposite; electric field; heat dissipation energy; photothermal effect in potential therapy PTT; surface-enhanced Raman spectroscopy (SERS); surface plasmon resonance; RESONANCE; NANOMEDICINE; HEAT;
D O I
10.2217/nnm-2020-0385
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aim: To prepare efficient metal-semiconductor nanoparticles as noninvasive, real-time imaging probes for photothermal therapy (PTT) applications. Materials & methods: A bottom-up approach was used to fabricate core-shell Ag@CuS nanoparticles (NPs). PTT and Raman mapping were done using HeLa cells. Theoretical simulation of electric field enhancement and heat dissipation density of Ag@CuS NPs was performed. Results: PTT-induced hyperthermia was achieved under 940 nm near-infrared light irradiation. Surface-enhanced Raman spectroscopy (SERS) signals of dye molecules were observed when conjugated with Ag@CuS NPs. Conclusion: Ag@CuS NPs are found to be efficient for SERS imaging and localized heating under laser irradiation, making a promising candidate for SERS-guided PTT.
引用
收藏
页码:909 / 923
页数:16
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