Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?

被引：18

作者：

Hossain, Farhad Md. ^{[1
,2
,3
]}

Hong, Yunkyung ^{[2
,3
,4
]}

Jin, Yunho ^{[2
,3
,4
,5
]}

Choi, Jeonghyun ^{[2
,3
,4
,5
]}

Hong, Yonggeun ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Inje Univ, Grad Sch, Dept Phys Therapy, Gimhae 50834, South Korea

[2] Inje Univ, U HARC, Gimhae 50834, South Korea

[3] Inje Univ, BPRC, Gimhae 50834, South Korea

[4] Inje Univ, Grad Sch, Dept Rehabil Sci, Gimhae 50834, South Korea

[5] Inje Univ, Coll Healthcare Med Sci & Engn, Dept Phys Therapy, Gimhae 50834, South Korea

[6] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 09期

关键词：

osteoarthritis; melatonin; thyroid-stimulating hormone; cortisol; circadian clock; THYROTROPIN-RELEASING-HORMONE; INTRACELLULAR PROOXIDANT ACTIVITY; STIMULATED OSTEOCALCIN SYNTHESIS; REACTIVE OXYGEN; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; ARTICULAR-CARTILAGE; CORTISOL PRODUCTION; OXIDATIVE DAMAGE; GENE-EXPRESSION;

D O I：

10.3390/jcm8091415

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoarthritis (OA), the most common form of arthritis, may be triggered by improper secretion of circadian clock-regulated hormones, such as melatonin, thyroid-stimulating hormone (TSH), or cortisol. The imbalance of these hormones alters the expression of pro-inflammatory cytokines and cartilage degenerative enzymes in articular cartilage, resulting in cartilage erosion, synovial inflammation, and osteophyte formation, the major hallmarks of OA. In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock. We also highlight the effects of melatonin, TSH, and cortisol at different concentrations both in vivo and in vitro, which may help to elucidate the relationship between circadian hormones and OA.

引用

页数：17

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