Gender and Autoimmune Liver Diseases: Relevant Aspects in Clinical Practice

被引:16
作者
Invernizzi, Federica [1 ]
Cilla, Marta [1 ]
Trapani, Silvia [2 ]
Guarino, Maria [3 ]
Cossiga, Valentina [3 ]
Gambato, Martina [4 ]
Morelli, Maria Cristina [5 ]
Morisco, Filomena [3 ]
Burra, Patrizia [4 ]
Floreani, Annarosa [6 ,7 ]
机构
[1] IRCCS Osped San Raffaele, Div Internal Med & Hepatol, Ctr Liver Dis, I-20132 Milan, Italy
[2] Italian Natl Transplant Ctr, Natl Inst Hlth, I-00162 Rome, Italy
[3] Univ Naples Federico II, Dept Clin Med & Surg, Gastroenterol & Hepatol Unit, I-80138 Naples, Italy
[4] Univ Hosp Padova, Dept Surg Oncol & Gastroenterol Sci, Multivisceral Transplant Unit Gastroenterol, I-35128 Padua, Italy
[5] IRCCS Azienda Osped Univ Bologna, Internal Med Unit Treatment Severe Organ Failure, I-40138 Bologna, Italy
[6] IRCCS Negrar, I-37024 Verona, Italy
[7] Univ Padua, I-35131 Padua, Italy
来源
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 06期
关键词
gender; autoimmune liver diseases; autoimmune hepatitis primary biliary cirrhosis; primary sclerosing cholangitis; overlap syndromes; liver transplant; PRIMARY BILIARY-CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; INFLAMMATORY-BOWEL-DISEASE; POPULATION-BASED EPIDEMIOLOGY; LONG-TERM PROGNOSIS; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID; OVERLAP SYNDROME; RISK-FACTORS; FOLLOW-UP;
D O I
10.3390/jpm12060925
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Autoimmune liver diseases (AILDs) include autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. The etiologies of AILD are not well understood but appear to involve a combination of genetic and environmental factors. AILDs commonly affect young individuals and are characterized by a highly variable clinical course. These diseases significantly influence quality of life and can progress toward liver decompensation or the onset of hepatocellular or cholangiocarcinoma; a significant number of patients eventually progress to end-stage liver disease, requiring liver transplantation. In this review, we focus on the sex characteristics and peculiarities of AILD patients and highlight the relevance of a sex-specific analysis in future studies. Understanding the sex differences underlying AILD immune dysregulation may be critical for developing more effective treatments.
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页数:16
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