Two new eremophilane-type sesquiterpenes from the fresh roots of Rehmannia glutinosa

被引：12
作者：
Liu, Yan-Ling [1 ,2 ]
Cao, Yan-Gang [1 ,2 ]
Kan, Yu-Xuan [1 ,2 ]
Ren, Ying-Jie [1 ,2 ]
Zeng, Meng-nan [1 ,2 ]
Wang, Meng-na [1 ,2 ]
He, Chen [1 ,2 ]
Chen, Xu [1 ,2 ]
Zheng, Xiao-ke [1 ,2 ]
Feng, Wei-sheng [1 ,2 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov Chi, Zhengzhou 450046, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2021年 / 42卷
关键词：
Scrophulariaceae; Rehmannia glutinosa; Eremophilane; Renoprotective activity; IONONE GLYCOSIDES; CATALPOL;
D O I：
10.1016/j.phytol.2020.12.004
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new eremophilane-type sesquiterpenes, remophilanetriol A (1) and remophilanetriol B (2), together with two known compounds, diincarvilone C (3) and diincarvilone D (4), were isolated from the fresh roots of Rehmannia glutinosa. The structures were determined based on analysis of the IR, UV, MS, and NMR data. The absolute configurations of the new compounds were resolved by comparing their experimental and calculated ECD spectra. All compounds were tested for their protective effects on normal rat kidney tubule epithelioid (NRK-52e) cells injury induced by lipopolysaccharide (LPS). The results showed that compounds 1 and 2 exhibited protective effects against LPS-induced damage to NRK-52e cells.
引用
收藏
页码：125 / 128
页数：4
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