COV-BT Ire study: safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with brain tumors

被引：6

作者：

Tanzilli, Antonio ^{[1
]}

Pace, Andrea ^{[1
]}

Ciliberto, Gennaro ^{[2
]}

La Malfa, Antonia Marina ^{[3
]}

Buonomo, Valentina ^{[1
]}

Benincasa, Dario ^{[1
]}

Biscu, Annamaria ^{[1
]}

Galie, Edvina ^{[1
]}

Villani, Veronica ^{[1
]}

机构：

[1] IRCCS Natl Canc Inst Regina Elena, Neurooncol Unit, Via Elio Chianesi 53, I-00144 Rome, Italy

[2] IRCCS Natl Canc Inst Regina Elena, Sci Direct, Via Elio Chianesi 53, I-00144 Rome, Italy

[3] IRCCS Regina Elena Natl Canc Inst, Hosp Pharm, Via Elio Chianesi 53, I-00144 Rome, Italy

来源：

NEUROLOGICAL SCIENCES | 2022年 / 43卷 / 06期

关键词：

COVID-19; Vaccine; Efficacy; Safety; Brain tumors;

D O I：

10.1007/s10072-022-06054-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The BNT162b2 vaccine conferred 95% protection against COVID-19 in people aged 16 years or older. Objective The aim of this observational study was to evaluate safety and efficacy of vaccine in patients affected by primary brain tumor (PBT). Methods We proposed COVID-19 vaccine to all patients affected by PBT followed by Neuroncology Unit of National Cancer Institute Regina Elena. Results 102 patients received the first dose, 100 the second, and 73 patients received the booster dose. After first dose, we observed one patient with fever and severe fatigue, while after the second one, we recorded adverse events in ten patients. No correlation was observed between adverse events and comorbidities. Conclusions The COVID-19 vaccine is safe and well tolerated in PBT patients.

引用

页码：3519 / 3522

页数：4

共 8 条

[1] Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients [J].

Abdul-Jawad, Sultan ;

Bau, Luca ;

Alaguthurai, Thanussuyah ;

del Barrio, Irene del Molino ;

Laing, Adam G. ;

Hayday, Thomas S. ;

Monin, Leticia ;

Munoz-Ruiz, Miguel ;

McDonald, Louisa ;

Quijorna, Isaac Francos ;

McKenzie, Duncan ;

Davis, Richard ;

Lorenc, Anna ;

Chan, Julie Nuo En ;

Ryan, Sarah ;

Bugallo-Blanco, Eva ;

Yorke, Rozalyn ;

Kamdar, Shraddha ;

Fish, Matthew ;

Zlatareva, Iva ;

Vantourout, Pierre ;

Jennings, Aislinn ;

Gee, Sarah ;

Doores, Katie ;

Bailey, Katharine ;

Hazell, Sophie ;

De Naurois, Julien ;

Moss, Charlotte ;

Russell, Beth ;

Khan, Aadil A. ;

Rowley, Mark ;

Benjamin, Reuben ;

Enting, Deborah ;

Alrifai, Doraid ;

Wu, Yin ;

Zhou, You ;

Barber, Paul ;

Ng, Tony ;

Spicer, James ;

Van Hemelrijck, Mieke ;

Kumar, Mayur ;

Vidler, Jennifer ;

Lwin, Yadanar ;

Fields, Paul ;

Karagiannis, Sophia N. ;

Coolen, Anthony C. C. ;

Rigg, Anne ;

Papa, Sophie ;

Hayday, Adrian C. ;

Patten, Piers E. M. .

CANCER CELL, 2021, 39 (02) :257-+

[2] Serologic response to COVID-19 infection and/or vaccine in cancer patients on active treatment [J].

Grinshpun, A. ;

Rottenberg, Y. ;

Ben-Dov, I. Z. ;

Djian, E. ;

Wolf, D. G. ;

Kadouri, L. .

ESMO OPEN, 2021, 6 (06)

[3] Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study [J].

Kuderer, Nicole M. ;

Choueiri, Toni K. ;

Shah, Dimpy P. ;

Shyr, Yu ;

Rubinstein, Samuel M. ;

Rivera, Donna R. ;

Shete, Sanjay ;

Hsu, Chih-Yuan ;

Desai, Aakash ;

Lopes, Gilberto de Lima, Jr. ;

Grivas, Petros ;

Painter, Corrie A. ;

Peters, Solange ;

Thompson, Michael A. ;

Bakouny, Ziad ;

Batist, Gerald ;

Bekaii-Saab, Tanios ;

Bilen, Mehmet A. ;

Bouganim, Nathaniel ;

Larroya, Mateo Bover ;

Castellano, Daniel ;

Del Prete, Salvatore A. ;

Doroshow, Deborah B. ;

Egan, Pamela C. ;

Elkrief, Arielle ;

Farmakiotis, Dimitrios ;

Flora, Daniel ;

Galsky, Matthew D. ;

Glover, Michael J. ;

Griffiths, Elizabeth A. ;

Gulati, Anthony P. ;

Gupta, Shilpa ;

Hafez, Navid ;

Halfdanarson, Thorvardur R. ;

Hawley, Jessica E. ;

Hsu, Emily ;

Kasi, Anup ;

Khaki, Ali R. ;

Lemmon, Christopher A. ;

Lewis, Colleen ;

Logan, Barbara ;

Masters, Tyler ;

McKay, Rana R. ;

Mesa, Ruben A. ;

Morgans, Alicia K. ;

Mulcahy, Mary F. ;

Panagiotou, Orestis A. ;

Peddi, Prakash ;

Pennell, Nathan A. ;

Reynolds, Kerry .

LANCET, 2020, 395 (10241) :1907-1918

[4]

Laing AG, 2020, NAT MED, V26, P1623, DOI 10.1038/s41591-020-1038-6

[5] Survival study of hospitalised patients with concurrent COVID-19 and haematological malignancies [J].

Martin-Moro, Fernando ;

Marquet, Juan ;

Piris, Miguel ;

Michael, Berta M. ;

Saez, Adolfo J. ;

Corona, Magdalena ;

Jimenez, Carlos ;

Astibia, Beatriz ;

Garcia, Irene ;

Rodriguez, Eulalia ;

Garcia-Hoz, Carlota ;

Fortun-Abete, Jesus ;

Herrera, Pilar ;

Lopez-Jimenez, Javier .

BRITISH JOURNAL OF HAEMATOLOGY, 2020, 190 (01) :E16-E20

[6] Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study [J].

Monin, Leticia ;

Laing, Adam G. ;

Munoz-Ruiz, Miguel ;

McKenzie, Duncan R. ;

Del Barrio, Irene Del Molino ;

Alaguthurai, Thanussuyah ;

Domingo-Vila, Clara ;

Hayday, Thomas S. ;

Graham, Carl ;

Seow, Jeffrey ;

Abdul-Jawad, Sultan ;

Kamdar, Shraddha ;

Harvey-Jones, Elizabeth ;

Graham, Rosalind ;

Cooper, Jack ;

Khan, Muhammad ;

Vidler, Jennifer ;

Kakkassery, Helen ;

Sinha, Shubhankar ;

Davis, Richard ;

Dupont, Liane ;

Quijorna, Isaac Francos ;

O'Brien-Gore, Charlotte ;

Lee, Puay Ling ;

Eum, Josephine ;

Poole, Maria Conde ;

Joseph, Magdalene ;

Davies, Daniel ;

Wu, Yin ;

Swampillai, Angela ;

North, Bernard, V ;

Montes, Ana ;

Harries, Mark ;

Rigg, Anne ;

Spicer, James ;

Malim, Michael H. ;

Fields, Paul ;

Patten, Piers ;

Di Rosa, Francesca ;

Papa, Sophie ;

Tree, Timothy ;

Doores, Katie J. ;

Hayday, Adrian C. ;

Irshad, Sheeba .

LANCET ONCOLOGY, 2021, 22 (06) :765-778

[7] Fifth-week immunogenicity and safety of anti-SARS-CoV-2 BNT162b2 vaccine in patients with multiple myeloma and myeloproliferative malignancies on active treatment: preliminary data from a single institution [J].

Pimpinelli, Fulvia ;

Marchesi, Francesco ;

Piaggio, Giulia ;

Giannarelli, Diana ;

Papa, Elena ;

Falcucci, Paolo ;

Pontone, Martina ;

Di Martino, Simona ;

Laquintana, Valentina ;

La Malfa, Antonia ;

Di Domenico, Enea Gino ;

Di Bella, Ornella ;

Falzone, Gianluca ;

Ensoli, Fabrizio ;

Vujovic, Branka ;

Morrone, Aldo ;

Ciliberto, Gennaro ;

Mengarelli, Andrea .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)

[8] Factors associated with COVID-19-related death using OpenSAFELY [J].

Williamson, Elizabeth J. ;

Walker, Alex J. ;

Bhaskaran, Krishnan ;

Bacon, Seb ;

Bates, Chris ;

Morton, Caroline E. ;

Curtis, Helen J. ;

Mehrkar, Amir ;

Evans, David ;

Inglesby, Peter ;

Cockburn, Jonathan ;

McDonald, Helen, I ;

MacKenna, Brian ;

Tomlinson, Laurie ;

Douglas, Ian J. ;

Rentsch, Christopher T. ;

Mathur, Rohini ;

Wong, Angel Y. S. ;

Grieve, Richard ;

Harrison, David ;

Forbes, Harriet ;

Schultze, Anna ;

Croker, Richard ;

Parry, John ;

Hester, Frank ;

Harper, Sam ;

Perera, Rafael ;

Evans, Stephen J. W. ;

Smeeth, Liam ;

Ben Goldacre .

NATURE, 2020, 584 (7821) :430-+

← 1 →