Not lost in host translation: The new roles of long noncoding RNAs in infectious diseases

被引：3

作者：

Reisacher, Caroline ^{[1
]}

Arbibe, Laurence ^{[1
]}

机构：

[1] Univ Paris 05, CNRS UMR 8253, INSERM U1151, Dept Immunol Infectiol & Hematol,INEM, Paris, France

来源：

CELLULAR MICROBIOLOGY | 2019年 / 21卷 / 11期

关键词：

MESSENGER-RNA; REVEALS; PEPTIDES; PROTEIN; DIFFERENTIATION; IDENTIFICATION; COMPLEXITY; EVOLUTION; DISCOVERY; GENE;

D O I：

10.1111/cmi.13119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long non-coding RNAs (lncRNAs) play a central role in the regulation of gene expression. Although they were initially described as mRNA-like transcripts not encoding proteins, global approaches such as ribosome profiling have shown that they frequently associate with ribosomes, opening the possibility that lncRNAs are a source of cryptic translation events with functional roles. Recent studies have shed more light on small ORFs borne by lncRNAs and encoding short peptides potentially involved in infectious immunity. This review outlines the main strategies used to determine the coding potential of lncRNAs and discusses our emerging understanding of the implication of the encoded peptides in infectious diseases.

引用

收藏

页数：7

相关论文

共 54 条

[1] Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation [J].

Bazzini, Ariel A. ;

Johnstone, Timothy G. ;

Christiano, Romain ;

Mackowiak, Sebastian D. ;

Obermayer, Benedikt ;

Fleming, Elizabeth S. ;

Vejnar, Charles E. ;

Lee, Miler T. ;

Rajewsky, Nikolaus ;

Walther, Tobias C. ;

Giraldez, Antonio J. .

EMBO JOURNAL, 2014, 33 (09) :981-993

[2] Global identification of human transcribed sequences with genome tiling arrays [J].

Bertone, P ;

Stolc, V ;

Royce, TE ;

Rozowsky, JS ;

Urban, AE ;

Zhu, XW ;

Rinn, JL ;

Tongprasit, W ;

Samanta, M ;

Weissman, S ;

Gerstein, M ;

Snyder, M .

SCIENCE, 2004, 306 (5705) :2242-2246

[3] Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition [J].

Bosson, Andrew D. ;

Zamudio, Jesse R. ;

Sharp, Phillip A. .

MOLECULAR CELL, 2014, 56 (03) :347-359

[4] Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization [J].

Carlevaro-Fita, Joana ;

Johnson, Rory .

MOLECULAR CELL, 2019, 73 (05) :869-883

[5] Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells [J].

Carlevaro-Fita, Joana ;

Rahim, Anisa ;

Guigo, Roderic ;

Vardy, Leah A. ;

Johnson, Rory .

RNA, 2016, 22 (06) :867-882

[6] Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat [J].

Carrieri, Claudia ;

Cimatti, Laura ;

Biagioli, Marta ;

Beugnet, Anne ;

Zucchelli, Silvia ;

Fedele, Stefania ;

Pesce, Elisa ;

Ferrer, Isidre ;

Collavin, Licio ;

Santoro, Claudio ;

Forrest, Alistair R. R. ;

Carninci, Piero ;

Biffo, Stefano ;

Stupka, Elia ;

Gustincich, Stefano .

NATURE, 2012, 491 (7424) :454-+

[7] Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations [J].

Chen, Xun ;

Dickman, Dion .

PLOS GENETICS, 2017, 13 (12)

[8] The steroid receptor RNA activator is the first functional RNA encoding a protein [J].

Chooniedass-Kothari, S ;

Emberley, E ;

Hamedani, MK ;

Troup, S ;

Wang, X ;

Czosnek, A ;

Hube, F ;

Mutawe, M ;

Watson, PH ;

Leygue, E .

FEBS LETTERS, 2004, 566 (1-3) :43-47

[9] Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance [J].

Denzler, Remy ;

Agarwal, Vikram ;

Stefano, Joanna ;

Bartel, David P. ;

Stoffel, Markus .

MOLECULAR CELL, 2014, 54 (05) :766-776

[10] The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration [J].

Dey, Bijan K. ;

Pfeifer, Karl ;

Dutta, Anindya .

GENES & DEVELOPMENT, 2014, 28 (05) :491-501

← 1 2 3 4 5 6 →