F-18 FDG PET/CT Findings in A Case of T-Cell Lymphoma-Associated Hemophagocytic Syndrome With Liver Involvement

被引：21

作者：

Suga, Kazuyoshi ^{[1
]}

Kawakami, Yasuhiko ^{[1
]}

Hiyama, Atsuto ^{[1
]}

Matsunaga, Naofumi ^{[2
]}

Imoto, Shinobu ^{[3
]}

Fukuda, Naofumi ^{[3
]}

Miyazaki, Mutsuko ^{[3
]}

机构：

[1] St Hill Hosp, Dept Radiol, Yamaguchi 7550151, Japan

[2] Yamaguchi Univ, Dept Radiol, Sch Med, Yamaguchi, Japan

[3] Ube Kousan Cent Hosp, Dept Hematol, Ube, Yamaguchi, Japan

来源：

CLINICAL NUCLEAR MEDICINE | 2010年 / 35卷 / 02期

关键词：

F-18 FDG PET/CT; T-cell lymphoma; hemophagocytic syndrome; liver involvement; PERIPORTAL LOW ATTENUATION; NON-HODGKIN-LYMPHOMA; COMPUTED-TOMOGRAPHY; CT; DISEASE; INFILTRATION; LAPAROTOMY; SPECTRUM; PATTERNS; SPLEEN;

D O I：

10.1097/RLU.0b013e3181c7bf20

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This is a report of fluoro-deoxy-glucose positron emission tomography/computed tomography (F-18-FDG PET/CT) findings in a case of T-cell lymphoma-associated hemophagocytic syndrome, with "periportal low attenuation" and edematous gall-bladder wall thickening. FDG PET/CT showed diffuse intense FDG uptake in the enlarged liver and spleen, with systemic FDG-avid lymphadenopathy including the hepatic hilar nodes. Fused plain CT and subsequent contrast-enhanced CT showed no hepatic parenchymal architectural abnormality but periportal low attenuation and edematous gallbladder wall thickening without FDG uptake. The second FDG PET/CT at 6 months after chemoimmunotherapy showed disappearance of the systemic abnormal FDG uptake including the enlarged hepatic hilar nodes and periportal/gall bladder abnormalities, with improvement of hepatosplenomegaly and laboratory data. This case suggests that FDG PET/CT is useful for detecting hepatic involvement of lymphoma and secondary-activated histiocytes causing a hemophagocytic syndrome, and that periportal low attenuation and an edematous gallbladder wall can be an indirect sign of lymphatic obstruction caused by FDG-avid hepatic hilar lymphadenopathy.

引用

页码：116 / 120

页数：5

共 28 条

[1] Patterns of liver infiltration in lymphoproliferative disease [J].

Baumhoer, D. ;

Tzankov, A. ;

Dirnhofer, S. ;

Tornillo, L. ;

Terracciano, L. M. .

HISTOPATHOLOGY, 2008, 53 (01) :81-90

[2]

CARROLL BA, 1983, J ULTRAS MED, V2, P89

[3]

Cissé R, 2004, J RADIOL, V85, P1729

[4] Non-Hodgkin lymphoma as a cause of intrahepatic periportal low attenuation on CT [J].

Coakley, FV ;

OReilly, EM ;

Schwartz, LH ;

Panicek, DM ;

Castellino, RA .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1997, 21 (05) :726-728

[5] Primary non-Hodgkin's lymphomas of the liver with nodular and diffuse infiltration patterns have different prognoses [J].

Emile, JF ;

Azoulay, D ;

Gornet, JM ;

Lopes, G ;

Delvart, V ;

Samuel, D ;

Reynès, M ;

Bismuth, H ;

Goldwasser, F .

ANNALS OF ONCOLOGY, 2001, 12 (07) :1005-1010

[6] CT OF LYMPHOMA - SPECTRUM OF DISEASE [J].

FISHMAN, EK ;

KUHLMAN, JE ;

JONES, RJ .

RADIOGRAPHICS, 1991, 11 (04) :647-669

[7] Extranodal Hodgkin disease:: Spectrum of disease [J].

Guermazi, A ;

Brice, P ;

de Kerviler, E ;

Fermé, C ;

Hennequin, C ;

Meignin, V ;

Frija, J .

RADIOGRAPHICS, 2001, 21 (01) :161-179

[8]

Harris AC, 1996, CANCER, V78, P2011, DOI 10.1002/(SICI)1097-0142(19961101)78:9<2011::AID-CNCR24>3.0.CO

[9]

2-Z

[10]

Iyama Satoshi, 2008, Gan To Kagaku Ryoho, V35, P1623

← 1 2 3 →