Immune reconstitution syndromes in human immunodeficiency virus infection following effective antiretroviral therapy

被引：39

作者：

Behrens, GMN ^{[1
]}

Meyer, D ^{[1
]}

Stoll, M ^{[1
]}

Schmidt, RE ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Clin Immunol, D-30623 Hannover, Germany

来源：

IMMUNOBIOLOGY | 2000年 / 202卷 / 02期

关键词：

D O I：

10.1016/S0171-2985(00)80065-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effective antiretroviral therapy leads to rapid decrease in plasma HIV-I RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic disorders. Here we describe cases of unusual clinical inflammatory syndromes in CMV retinitis, hepatitis C, and atypical mycobacteriosis in HIV-1 infected patients associated with the initiation of antiretroviral therapy. Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed.

引用

页码：186 / 193

页数：8

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