Invasive Aspergillosis associated with Covid-19: A word of caution

被引：12

作者：

Gouzien, Laura ^{[1
]}

Cocherie, Theophile ^{[2
]}

Eloy, Odile ^{[2
]}

Legriel, Stephane ^{[1
,4
]}

Bedos, Jean-Pierre ^{[1
]}

Simon, Christelle ^{[3
]}

Marque-Juillet, Stephanie ^{[2
]}

Ferre, Alexis ^{[1
]}

Bruneel, Fabrice ^{[1
]}

机构：

[1] Ctr Hosp Versailles, Site Andre Mignot, Intens Care Unit, 177 Rue Versailles, F-78150 Le Chesnay, France

[2] Ctr Hosp Versailles, Microbiol Lab, Le Chesnay, France

[3] Ctr Hosp Versailles, Anesthesiol Dept, Le Chesnay, France

[4] Univ Paris Saclay, UVSQ, INSERM, CESP,Team DevPsy, F-94807 Villejuif, France

来源：

INFECTIOUS DISEASES NOW | 2021年 / 51卷 / 04期

关键词：

Aspergillosis; Coronavirus Infections/pathology; COVID-19; Pulmonary Aspergillosis/diagnosis;

D O I：

10.1016/j.idnow.2020.12.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Invasive pulmonary aspergillosis is a well-known complication of acute respiratory distress syndrome, the most serious manifestation of COVID-19. Four recent studies have reported its incidence among ICU COVID-19 patients. However, they do not share the same case definition, and have provided conflicting results. In this paper we have aimed at reported the incidence of invasive pulmonary aspergillosis for COVID-19 patients in our ICU, and at comparing the different definitions in order to assess their respective relevance. Methods: Retrospective cohort study of critically ill patients with severe COVID-19 requiring ICU management between 1st March and 30th April 2020. Results: Our results showed significantly lower incidence of invasive pulmonary aspergillosis (1.8%;1/53), compared to three out of four previous studies, and wide variation in the numbers of cases with regard to the different definitions. Conclusion: Large-scale studies are needed for a better definition and a more accurate estimation of invasive pulmonary aspergillosis coinfection during COVID-19. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页码：383 / 386

页数：4

共 14 条

[1]

Alanio A, 2020, LANCET RESP MED, DOI [10.1016/S22112600(20)30237-X15221326002030237X1, DOI 10.1016/S22112600(20)30237-X15221326002030237X1]

[2]

Bartoletti M, 2020, Clin Infect Dis Off Publ Infect Dis Soc Am, V73, P1, DOI DOI 10.1093/CID/CIAA1065

[3] Bacterial and fungal superinfections in critically ill patients with COVID-19 [J].

Bassetti, Matteo ;

Kollef, Marin H. ;

Timsit, Jean-Francois .

INTENSIVE CARE MEDICINE, 2020, 46 (11) :2071-2074

[4] A Clinical Algorithm to Diagnose Invasive Pulmonary Aspergillosis in Critically Ill Patients [J].

Blot, Stijn I. ;

Taccone, Fabio Silvio ;

Van den Abeele, Anne-Marie ;

Bulpa, Pierre ;

Meersseman, Wouter ;

Brusselaers, Nele ;

Dimopoulos, George ;

Paiva, Jose A. ;

Misset, Benoit ;

Rello, Jordi ;

Vandewoude, Koenraad ;

Vogelaers, Dirk .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :56-64

[5] Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium [J].

Donnelly, J. Peter ;

Chen, Sharon C. ;

Kauffman, Carol A. ;

Steinbach, William J. ;

Baddley, John W. ;

Verweij, Paul E. ;

Clancy, Cornelius J. ;

Wingard, John R. ;

Lockhart, Shawn R. ;

Groll, Andreas H. ;

Sorrell, Tania C. ;

Bassetti, Matteo ;

Akan, Hamdi ;

Alexander, Barbara D. ;

Andes, David ;

Azoulay, Elie ;

Bialek, Ralf ;

Bradsher, Robert W., Jr. ;

Bretagne, Stephane ;

Calandra, Thierry ;

Caliendo, Angela M. ;

Castagnola, Elio ;

Cruciani, Mario ;

Cuenca-Estrella, Manuel ;

Decker, Catherine F. ;

Desai, Sujal R. ;

Fisher, Brian ;

Harrison, Thomas ;

Heussel, Claus Peter ;

Jensen, Henrik E. ;

Kibbler, Christopher C. ;

Kontoyiannis, Dimitrios P. ;

Kullberg, Bart-Jan ;

Lagrou, Katrien ;

Lamoth, Frederic ;

Lehrnbecher, Thomas ;

Loeffler, Jurgen ;

Lortholary, Olivier ;

Maertens, Johan ;

Marchetti, Oscar ;

Marr, Kieren A. ;

Masur, Henry ;

Meis, Jacques F. ;

Morrisey, C. Orla ;

Nucci, Marcio ;

Ostrosky-Zeichner, Luis ;

Pagano, Livio ;

Patterson, Thomas F. ;

Perfect, John R. ;

Racil, Zdenek .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1367-1376

[6] Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response [J].

Grasselli, Giacomo ;

Pesenti, Antonio ;

Cecconi, Maurizio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1545-1546

[7] COVID-19 associated pulmonary aspergillosis [J].

Koehler, Philipp ;

Cornely, Oliver A. ;

Boettiger, Bernd W. ;

Dusse, Fabian ;

Eichenauer, Dennis A. ;

Fuchs, Frieder ;

Hallek, Michael ;

Jung, Norma ;

Klein, Florian ;

Persigehl, Thorsten ;

Rybniker, Jan ;

Kochanek, Matthias ;

Boell, Boris ;

Shimabukuro-Vornhagen, Alexander .

MYCOSES, 2020, 63 (06) :528-534

[8]

Lamoth F, 2020, CLIN MICROBIOL INFEC, DOI [10.1016/j.emi.2020.07.010, DOI 10.1016/J.EMI.2020.07.010]

[9]

Saint Leger P, 2020, MED MALAD INFECT, V50, P586, DOI [10.1016/j.medmal.2020.06.173, DOI 10.1016/J.MEDMAL.2020.06.173]

[10] Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study [J].

Schauwvlieghe, Alexander F. A. D. ;

Rijnders, Bart J. A. ;

Philips, Nele ;

Verwijs, Rosanne ;

Vanderbeke, Lore ;

Van Tienen, Carla ;

Lagrou, Katrien ;

Verweij, Paul E. ;

Van de Veerdonk, Frank L. ;

Gommers, Diederik ;

Spronk, Peter ;

Bergmans, Dennis C. J. J. ;

Hoedemaekers, Astrid ;

Andrinopoulou, Eleni-Rosalina ;

van den Berg, Charlotte H. S. B. ;

Juffermans, Nicole P. ;

Hodiamont, Casper J. ;

Vonk, Alieke G. ;

Depuydt, Pieter ;

Boelens, Jerina ;

wauters, Joost .

LANCET RESPIRATORY MEDICINE, 2018, 6 (10) :782-792

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