Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes

被引：8

作者：

Farooqi, Ammad Ahmad ^{[1
]}

Kapanova, Gulnara ^{[2
,3
]}

Kussainov, Abay Z. ^{[4
]}

Datkhayeva, Zaure ^{[5
]}

Raganina, Karlygash ^{[6
]}

Sadykov, Bolat N. ^{[7
]}

机构：

[1] Inst Biomed & Genet Engn IBGE, Islamabad, Pakistan

[2] Al Farabi Kazakh Natl Univ, 71 al Farabi Ave, Alma Ata 050040, Kazakhstan

[3] Sci Ctr Anti Infect Drugs, 75 al Faraby Ave, Kazakhstan 050040, Kazakhstan

[4] Kazakh Natl Med Univ, Dept Pediat Surg, Alma Ata, Kazakhstan

[5] Kazakh Natl Med Univ, Dept Obstet & Gynecol, Alma Ata, Kazakhstan

[6] Asfendiyarov Kazakh Natl Med Univ, Dept Pharmaceut Technol, Alma Ata, Kazakhstan

[7] Kazakhstan Med Univ KSPH, Dept Gen Surg, Alma Ata 050004, Kazakhstan

来源：

NON-CODING RNA RESEARCH | 2022年 / 7卷 / 02期

关键词：

CELL-PROLIFERATION; COLORECTAL-CANCER; INHIBITS PROLIFERATION; EPIGENETIC REGULATION; GENE-EXPRESSION; DOWN-REGULATION; GASTRIC-CANCER; PROMOTES; OSTEOSARCOMA; METASTASIS;

D O I：

10.1016/j.ncrna.2022.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ras-association domain family (RASSF) proteins are tumor suppressors and have gained phenomenal limelight because of their mechanistic role in the prevention/ inhibition of carcinogenesis and metastasis. Decades of research have demystified wide ranging activities of RASSF molecules in multiple stages of cancers. Although major fraction of RASSF molecules has tumor suppressive roles, yet there is parallel existence of proof-of-concept about moonlighting activities of RASSF proteins as oncogenes. RASSF proteins tactfully rewire signaling cascades for prevention of cancer and metastasis but circumstantial evidence also illuminates oncogenic role of different RASSF proteins in different cancers. In this review we have attempted to provide readers an overview of the complex interplay between non-coding RNAs and RASSF proteins and how these versatile regulators shape the landscape of carcinogenesis and metastasis.

引用

页码：123 / 131

页数：9

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