The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres

被引：0

作者：

Rodrigues, JM

Lima, KD

Jensen, CED

de Aguiar, MMG

Cunha, AD

机构：

[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, Brazil

[2] Univ Fed Minas Gerais, Pharmaceut Technol Lab, Belo Horizonte, MG, Brazil

来源：

ARTIFICIAL ORGANS | 2003年 / 27卷 / 05期

关键词：

insulin; diabetes; cyclodextrins; microspheres; pulmonary administration; powder inhalation;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 mum. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration.

引用

页码：492 / 497

页数：6

共 16 条

[1]

AGUIAR MMG, IN PRESS ENCAPSULATI

[2] Minimization of Shaking-induced Formation of Insoluble Aggregates of Insulin by Cyclodextrins [J].