Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients

被引：25

作者：

Aoude, Lauren G. ^{[1
]}

Wong, Bernadette Z. Y. ^{[2
,3
]}

Bonazzi, Vanessa F. ^{[1
]}

Brosda, Sandra ^{[1
]}

Walters, Shaun B. ^{[4
]}

Koufariotis, Lambros T. ^{[5
]}

Naeini, Marjan M. ^{[5
]}

Pearson, John, V ^{[5
]}

Oey, Harald ^{[1
]}

Patel, Kalpana ^{[1
]}

Bradford, Julia J. ^{[1
]}

Bloxham, Conor J. ^{[1
]}

Atkinson, Victoria ^{[6
,7
]}

Law, Phillip ^{[2
]}

Strutton, Geoffrey ^{[8
]}

Bayley, Gerard ^{[6
]}

Yang, Samuel ^{[6
]}

Smithers, B. Mark ^{[6
,7
]}

Waddell, Nicola ^{[5
]}

Miles, Kenneth ^{[2
]}

Barbour, Andrew P. ^{[1
,6
]}

机构：

[1] Univ Queensland, Diamantina Inst, Woolloongabba, Qld, Australia

[2] Princess Alexandra Hosp, Dept Med Imaging, Woolloongabba, Qld, Australia

[3] Gold Coast Univ Hosp, Dept Med Imaging, Southport, Qld, Australia

[4] Univ Queensland, Sch Biomed Sci, St Lucia, Qld, Australia

[5] QIMR Berghofer Med Res Inst, Herston, Qld, Australia

[6] Princess Alexandra Hosp, Queensland Melanoma Project, Woolloongabba, Qld, Australia

[7] Univ Queensland, Fac Med, St Lucia, Qld, Australia

[8] Princess Alexandra Hosp, Dept Anat Pathol, Woolloongabba, Qld, Australia

来源：

MOLECULAR CANCER RESEARCH | 2021年 / 19卷 / 06期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

METASTATIC MELANOMA; SURVIVAL;

D O I：

10.1158/1541-7786.MCR-20-1038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techniques are necessary for the development of predictive/prognostic biomarkers. PET/CT scans from 52 patients with stage III/IV melanoma were assessed and CT image parameters were evaluated as prognostic biomarkers. Analysis indicated patients with high standard deviation or high mean of positive pixels (MPP) had worse progression-free survival (P = 0.00047 and P = 0.0014, respectively) and worse overall survival (P = 0.0223 and P = 0.0465, respectively). Whole-exome sequencing showed high MPP was associated with BRAF mutation status (P = 0.0389). RNA-sequencing indicated patients with immune "cold" signatures had worse survival, which was associated with CT biomarker, MPP4 (P = 0.0284). Multiplex immunofluorescence confirmed a correlation between CD8 expression and image biomarkers (P = 0.0028).

引用

页码：950 / 956

页数：7

共 22 条

[1]

[Anonymous], 2018, CA Cancer J Clin, V68, P394

[2] Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients [J].

Aoude, Lauren G. ;

Bonazzi, Vanessa F. ;

Brosda, Sandra ;

Patel, Kalpana ;

Koufariotis, Lambros T. ;

Oey, Harald ;

Nones, Katia ;

Wood, Scott ;

Pearson, John, V ;

Lonie, James M. ;

Arneil, Melissa ;

Atkinson, Victoria ;

Smithers, B. Mark ;

Waddell, Nicola ;

Barbour, Andrew P. .

SCIENTIFIC REPORTS, 2020, 10 (01)

[3] The tumour immune landscape and its implications in cutaneous melanoma [J].

Attrill, Grace H. ;

Ferguson, Peter M. ;

Palendira, Umaimainthan ;

Long, Georgina V. ;

Wilmott, James S. ;

Scolyer, Richard A. .

PIGMENT CELL & MELANOMA RESEARCH, 2021, 34 (03) :529-549

[4] RNA-SeQC: RNA-seq metrics for quality control and process optimization [J].

DeLuca, David S. ;

Levin, Joshua Z. ;

Sivachenko, Andrey ;

Fennell, Timothy ;

Nazaire, Marc-Danie ;

Williams, Chris ;

Reich, Michael ;

Winckler, Wendy ;

Getz, Gad .

BIOINFORMATICS, 2012, 28 (11) :1530-1532

[5] STAR: ultrafast universal RNA-seq aligner [J].

Dobin, Alexander ;

Davis, Carrie A. ;

Schlesinger, Felix ;

Drenkow, Jorg ;

Zaleski, Chris ;

Jha, Sonali ;

Batut, Philippe ;

Chaisson, Mark ;

Gingeras, Thomas R. .

BIOINFORMATICS, 2013, 29 (01) :15-21

[6] Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment [J].

Gajewski, Thomas F. ;

Corrales, Leticia ;

Williams, Jason ;

Horton, Brendan ;

Sivan, Ayelet ;

Spranger, Stefani .

TUMOR IMMUNE MICROENVIRONMENT IN CANCER PROGRESSION AND CANCER THERAPY, 2017, 1036 :19-31

[7] Approaches to treat immune hot, altered and cold tumours with combination immunotherapies [J].

Galon, Jerome ;

Bruni, Daniela .

NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (03) :197-218

[8] Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma [J].

Gide, Tuba N. ;

Wilmott, James S. ;

Scolyer, Richard A. ;

Long, Georgina V. .

CLINICAL CANCER RESEARCH, 2018, 24 (06) :1260-1270

[9] Whole-genome landscapes of major melanoma subtypes [J].

Hayward, Nicholas K. ;

Wilmott, James S. ;

Waddell, Nicola ;

Johansson, Peter A. ;

Field, Matthew A. ;

Nones, Katia ;

Patch, Ann-Marie ;

Kakavand, Hojabr ;

Alexandrov, Ludmil B. ;

Burke, Hazel ;

Jakrot, Valerie ;

Kazakoff, Stephen ;

Holmes, Oliver ;

Leonard, Conrad ;

Sabarinathan, Radhakrishnan ;

Mularoni, Loris ;

Wood, Scott ;

Xu, Qinying ;

Waddell, Nick ;

Tembe, Varsha ;

Pupo, Gulietta M. ;

De Paoli-Iseppi, Ricardo ;

Vilain, Ricardo E. ;

Shang, Ping ;

Lau, Loretta M. S. ;

Dagg, Rebecca A. ;

Schramm, Sarah-Jane ;

Pritchard, Antonia ;

Dutton-Regester, Ken ;

Newell, Felicity ;

Fitzgerald, Anna ;

Shang, Catherine A. ;

Grimmond, Sean M. ;

Pickett, Hilda A. ;

Yang, Jean Y. ;

Stretch, Jonathan R. ;

Behren, Andreas ;

Kefford, Richard F. ;

Hersey, Peter ;

Long, Georgina V. ;

Cebon, Jonathan ;

Shackleton, Mark ;

Spillane, Andrew J. ;

Saw, Robyn P. M. ;

Lopez-Bigas, Nuria ;

Pearson, John V. ;

Thompson, John F. ;

Scolyer, Richard A. ;

Mann, Graham J. .

NATURE, 2017, 545 (7653) :175-180

[10] Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma [J].

Katsoulakis, Evangelia ;

Yu, Yao ;

Apte, Aditya P. ;

Leeman, Jonathan E. ;

Katabi, Nora ;

Morris, Luc ;

Deasy, Joseph O. ;

Chan, Timothy A. ;

Lee, Nancy Y. ;

Riaz, Nadeem ;

Hatzoglou, Vaios ;

Oh, Jung Hun .

ORAL ONCOLOGY, 2020, 110

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