The macrophage migration inhibitory factor-glucocorticoid dyad: Regulation of inflammation and immunity

被引：208
作者：
Flaster, Harry
Bernhagen, Juergen
Calandra, Thierry
Bucala, Richard
机构：
[1] Yale Univ, Sch Med, Dept Med Pathol & Epidemiol & Publ Hlth, Anlyan Ctr, New Haven, CT 06520 USA
[2] Univ Hosp RWTH, Inst Biochem, D-52074 Aachen, Germany
[3] CHU Vaudois, Infect Dis Serv, Dept Med, CH-1011 Lausanne, Switzerland
来源：
MOLECULAR ENDOCRINOLOGY | 2007年 / 21卷 / 06期
关键词：
D O I：
10.1210/me.2007-0065
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cytokine macrophage migration inhibitory factor ( MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
引用
收藏
页码：1267 / 1280
页数：14
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