Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

被引：6
作者：
LeBlanc, Emmanuelle V. [1 ]
Kim, Youjin [1 ]
Capicciotti, Chantelle J. [1 ,2 ,3 ]
Colpitts, Che C. [1 ]
机构：
[1] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada
[3] Queens Univ, Dept Surg, Kingston, ON K7L 3N6, Canada
来源：
PATHOGENS | 2021年 / 10卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
hepatitis C virus; viral entry; glycans; vaccines; prophylaxis; N-LINKED GLYCANS; HCV ENVELOPE GLYCOPROTEINS; HYPERVARIABLE REGION 1; NEUTRALIZING ANTIBODIES; HEPARAN-SULFATE; E2; GLYCOPROTEIN; DC-SIGN; CELLULAR DETERMINANTS; URIDINE DERIVATIVES; MONOCLONAL-ANTIBODY;
D O I：
10.3390/pathogens10060685
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection.
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页数：19
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