Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity - initial experience and comparison to [18F]FDG PET/CT and MRI

被引：44

作者：

Linz, Christian ^{[1
,2
]}

Brands, Roman C. ^{[1
,2
]}

Kertels, Olivia ^{[2
,3
]}

Dierks, Alexander ^{[2
,4
,5
]}

Brumberg, Joachim ^{[2
,4
,6
]}

Gerhard-Hartmann, Elena ^{[2
,7
]}

Hartmann, Stefan ^{[1
]}

Schirbel, Andreas ^{[2
,4
]}

Serfling, Sebastian ^{[2
,4
]}

Zhi, Yingjun ^{[8
]}

Buck, Andreas K. ^{[2
,4
]}

Kuebler, Alexander ^{[1
,2
]}

Hohm, Julian ^{[1
]}

Lapa, Constantin ^{[2
,4
,5
]}

Kircher, Malte ^{[2
,4
,5
]}

机构：

[1] Univ Hosp Wurzburg, Dept Oral & Maxillofacial Plast Surg, Pleicherwall 2, D-97070 Wurzburg, Germany

[2] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Josef Schneider Str 6, D-97080 Wurzburg, Germany

[3] Univ Hosp Wurzburg, Inst Diagnost & Intervent Radiol, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany

[4] Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany

[5] Univ Augsburg, Med Fac, Nucl Med, Stenglinstr 2, D-86156 Augsburg, Germany

[6] Univ Hosp Freiburg, Dept Nucl Med, Hugstetter Str 55, D-79106 Freiburg, Germany

[7] Univ Wurzburg, Dept Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany

[8] Univ Hosp Wurzburg, Dept Otorhinolaryngol, Josef Schneider Str 11, D-97080 Wurzburg, Germany

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2021年 / 48卷 / 12期

关键词：

Molecular imaging; Fibroblast activation protein; Head and neck cancer; PET; STROMAL FIBROBLASTS; ENHANCED CT; NECK; HEAD; CANCER; CLASSIFICATION; METASTASES; F-18-FDG; INFLAMMATION; PREVALENCE;

D O I：

10.1007/s00259-021-05422-z

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose While [F-18]-fluorodeoxyglucose ([F-18]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake in inflammatory cells such as neutrophils or macrophages. Recently, molecular imaging probes targeting fibroblast activation protein alpha (FAP), which is overexpressed in a variety of cancer-associated fibroblasts, have become available and might constitute a feasible alternative to FDG PET/CT. Methods Ten consecutive, treatment-naive patients (8 males, 2 females; mean age, 62 +/- 9 years) with biopsy-proven OSCC underwent both whole-body [F-18]FDG and [Ga-68]FAPI-04 (FAP-directed) PET/CT for primary staging prior to tumor resection and cervical lymph node dissection. Detection of the primary tumor, as well as the presence and number of lymph node and distant metastases was analysed. Intensity of tracer accumulation was assessed by means of maximum (SUVmax) and peak (SUVpeak) standardized uptake values. Histological work-up including immunohistochemical staining for FAP served as standard of reference. Results [F-18]FDG and FAP-directed PET/CT detected all primary tumors with a SUVmax of 25.5 +/- 13.2 (FDG) and 20.5 +/- 6.4 (FAP-directed) and a SUVpeak of 16.1 +/- 10.3 ([F-18]FDG) and 13.8 +/- 3.9 (FAP-directed), respectively. Regarding cervical lymph node metastases, FAP-directed PET/CT demonstrated comparable sensitivity (81.3% vs. 87.5%; P = 0.32) and specificity (93.3% vs. 81.3%; P = 0.16) to [F-18]FDG PET/CT. FAP expression on the cell surface of cancer-associated fibroblasts in both primary lesions as well as lymph nodes metastases was confirmed in all samples. Conclusion FAP-directed PET/CT in OSCC seems feasible. Future research to investigate its potential to improve patient staging is highly warranted.

引用

页码：3951 / 3960

页数：10

共 47 条

[1] Reciprocal Interaction between Carcinoma-Associated Fibroblasts and Squamous Carcinoma Cells through Interleukin-1α Induces Cancer Progression [J].