C(sp3)-N Bond-Forming Reductive Elimination of Amines: Reactions of Bisphosphine-Ligated Benzylpalladium(II) Diarylamido Complexes

被引：49

作者：

Marquard, Seth L. ^{[1
]}

Rosenfeld, Devon C. ^{[1
]}

Hartwig, John F. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 04期

关键词：

amido complexes; C-N bond formation; dissociation; palladium; reductive elimination; HETEROCYCLIC CARBENE COMPLEXES; OXIDATIVE-ADDITION; PALLADIUM; CARBON; REACTIVITY; HYDROAMINATION; VINYLARENES; AMINATION; MECHANISM; ANILINES;

D O I：

10.1002/anie.200904032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A rare event: The benzylpalladium amido complex 1 (Ar= napthyl) was used to study the mechanism of an unusual reductive elimination of amines (see scheme). The observed inversion of configuration is proposed to result from dissociation of the amido ligand, followed by nucleophilic attack on the benzylic carbon atom. binap = 2,2′- bis(diphenylphosphanyl)-1,1′-binaphthyl, dppf=1,1′- bis(diphenylphosphanyl)ferrocene. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：793 / 796

页数：4

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