Alternative immunomodulators

被引：4

作者：

Forbes, A

机构：

[1] St Marks Hosp, Harrow HA1 3UJ, Middx, England

[2] Acad Inst, Harrow, Middx, England

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2003年 / 15卷 / 03期

关键词：

Crohn's disease; ulcerative colitis; eicosanoid; ICAM-1; interleukin; interferon; NF-kappa-B; mycophenolate; natalizumab; tacrolimus;

D O I：

10.1097/00042737-200303000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is now a large number of potential immunomodulatory agents that may be of value in inflammatory bowel disease. The newer immunosuppressants, such as tacrolimus and mycophenolate, probably offer little more than providing comparable alternatives to more established agents, and fish oil and other eicosanoid modulators are probably not especially potent if effective. The biological agents, however, bring a more novel and potentially powerful approach. Natalizumab, and targeted mucosal delivery of interleukin-10 already show considerable promise.

引用

收藏

页码：245 / 248

页数：4

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