PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System

被引：11
作者：
Shu, Linjing [1 ,2 ]
Huang, Renhuan [1 ]
Wu, Songtao [1 ]
Chen, Zhaozhao [1 ]
Sun, Ke [1 ]
Jiang, Yan [1 ]
Cai, Xiaoxiao [1 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,3rd Sec,Ren Min Nan Rd, Chengdu 610041, Sichuan Provinc, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Dept Oral Implantol Ctr, Chengdu 610041, Sichuan Provinc, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2016年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Antitumor; chemoprevention; digestive system; peroxisome proliferator-activated receptor gamma; thiazolidinediones (TZDs); tumor cells; ACTIVATED-RECEPTOR-GAMMA; INHIBITS CELL-GROWTH; PANCREATIC-CANCER CELLS; MOUSE COLON CARCINOGENESIS; CARCINOMA IN-VITRO; GASTRIC-CANCER; COLORECTAL-CANCER; LINOLEIC-ACID; PERITONEAL METASTASIS; INDUCED APOPTOSIS;
D O I：
10.2174/1574888X10666150630111618
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPAR gamma can suppress the growth of oral, esophageal, gastric, colorectal, liver, biliary, and pancreatic tumor cells, suggesting that PPAR gamma ligand is a potential anticancer agent in PPAR gamma-expressing tumors. This review highlights key advances in understanding the effects of PPAR gamma ligands in the treatment of tumors in the digestive system.
引用
收藏
页码：274 / 281
页数：8
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