A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

被引：219

作者：

Mok, Samuel C. ^{[2
]}

Bonome, Tomas ^{[1
]}

Vathipadiekal, Vinod ^{[1
]}

Bell, Aaron ^{[1
]}

Johnson, Michael E. ^{[5
]}

Wong, Kwong-kwok ^{[2
]}

Park, Dong-Choon ^{[5
,7
]}

Hao, Ke ^{[8
]}

Yip, Daniel K. P. ^{[9
]}

Donninger, Howard ^{[1
]}

Ozbun, Laurent ^{[1
]}

Samimi, Goli ^{[1
,3
]}

Brady, John ^{[4
]}

Randonovich, Mike ^{[4
]}

Pise-Masison, Cindy A. ^{[4
]}

Barrett, J. Carl ^{[1
]}

Wong, Wing H. ^{[8
]}

Welch, William R. ^{[6
]}

Berkowitz, Ross S. ^{[5
,10
]}

Birrer, Michael J. ^{[1
]}

机构：

[1] NCI, Cell & Canc Biol Branch, NIH, Rockville, MD 20892 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA

[3] NCI, Canc Prevent Fellowship Program, NIH, Rockville, MD 20892 USA

[4] NCI, Cellular Oncol Lab, NIH, Rockville, MD 20892 USA

[5] Harvard Univ, Sch Med, Dept Obstet Gynecol & Reprod Biol, Brigham & Womens Hosp,Div Gynecol Oncol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[7] Catholic Univ Korea, St Vincent Hosp, Dept Obstet & Gynecol, Suwon 442723, Gyeonggi Do, South Korea

[8] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[9] Univ S Florida, Dept Physiol & Biophys, Tampa, FL 33612 USA

[10] Dana Farber Harvard Canc Ctr, Gillette Ctr Womens Canc, Boston, MA 02115 USA

来源：

CANCER CELL | 2009年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

EXPRESSION PATTERNS; ENDOTHELIAL-CELLS; ADHESION; STATISTICS; CENTROSOME; INTEGRINS; INTERACTS; MAGP-2; TUMORS;

D O I：

10.1016/j.ccr.2009.10.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the alpha(V)beta(3) integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

引用

页码：521 / 532

页数：12

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