Inhibition of Helicobacter pylori and Its Associate Urease by Labdane Diterpenoids Isolated from Andrographis paniculata

被引：15

作者：

Shaikh, Rafik U. ^{[1
]}

Dawane, Ashwini A. ^{[2
]}

Pawar, Rajendra P. ^{[3
]}

Gond, Dhananjay S. ^{[4
]}

Meshram, Rohan J. ^{[2
]}

Gacche, Rajesh N. ^{[2
]}

机构：

[1] Poona Coll, Dept Bot, Pune 411001, MS, India

[2] Swami Ramanand Teerth Marathwada Univ, Sch Life Sci, Nanded 431606, MS, India

[3] Deogiri Coll, Dept Chem, Aurangabad 431005, MS, India

[4] Savitribai Phule Pune Univ, Dept Microbiol, Pune 411007, MS, India

来源：

PHYTOTHERAPY RESEARCH | 2016年 / 30卷 / 03期

关键词：

Helicobacter pylori; Andrographis paniculata; diterpenoids; urease; MEDICINAL-PLANTS; ANTIULCER ACTIVITY; NEES; LOCALIZATION; FLAVONOIDS; INFECTION; EXTRACTS; LEAVES;

D O I：

10.1002/ptr.5542

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study was carried out to evaluate anti-Helicobacter pylori and its associated urease activity of labdane diterpenoids isolated from Andrographis paniculata. A molecular docking analysis was performed by using ArgusLab 4.0.1 software. The results obtained indicate that compound A possesses strong inhibition to H. pylori, 28 +/- 2.98 (minimum inhibitory concentration, 9 mu g/mL), and its urease, 85.54 +/- 2.62% (IC50, 20.2 mu g/mL). Compounds B, C, and D also showed moderate inhibition to H. pylori and its urease. The obtained results were in agreement with the molecular docking analysis of compounds. The phytochemicals under investigation were found to be promising antibacterial agents. Moreover, the isolated compounds can be considered as a resource for searching novel anti-H. pylori agents possessing urease inhibition. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：412 / 417

页数：6

共 41 条

[1]

Ali SM, 2005, ANN CLIN MICROBIOL A

[2] Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release [J].