A new approach for an organocatalytic multicomponent domino asymmetric reaction

被引：227

作者：

Carlone, Armando ^{[1
]}

Cabrera, Silvia ^{[1
]}

Marigo, Mauro ^{[1
]}

Jorgensen, Karl Anker ^{[1
]}

机构：

[1] Aarhus Univ, Ctr Catalysis, Danish Natl Res Fdn, Dept Chem, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 07期

关键词：

aldehydes; asymmetry; domino reactions; multicomponent reactions; organocatalysis;

D O I：

10.1002/anie.200604479

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As easy as pouring! Three C-C bonds, up to three stereocenters, and ee values greater than 97% are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS = trimethylsilyl; EWG = electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1101 / 1104

页数：4

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