Evaluation of a newly proposed renal risk score for Japanese patients with ANCA-associated glomerulonephritis

被引:14
作者
Saito, Masaya [1 ]
Saito, Ayano [1 ]
Abe, Fumito [1 ,2 ]
Imaizumi, Chihiro [1 ]
Kaga, Hajime [1 ]
Sawamura, Masato [1 ]
Nara, Mizuho [1 ]
Ozawa, Masatoyo [3 ]
Sato, Ryuta [4 ]
Nakayama, Takahiro [5 ]
Okuyama, Shin [6 ]
Masai, Rie [7 ]
Ohtani, Hiroshi [3 ]
Komatsuda, Atsushi [8 ]
Wakui, Hideki [9 ]
Takahashi, Naoto [1 ]
机构
[1] Akita Univ, Grad Sch Med, Dept Hematol Nephrol & Rheumatol, 1-1-1 Hondo, Akita 0108543, Japan
[2] Yuri Kumiai Gen Hosp, Dept Internal Med, Akita, Japan
[3] Akita Kosei Med Ctr, Dept Nephrol, Akita, Japan
[4] Akita Red Cross Hosp, Dept Nephrol, Akita, Japan
[5] Nihonkai Gen Hosp, Dept Nephrol & Rheumatol, Yamagata, Japan
[6] Nakadori Gen Hosp, Dept Nephrol & Rheumatol, Akita, Japan
[7] Akita City Hosp, Dept Nephrol, Akita, Japan
[8] Ogachi Cent Hosp, Dept Internal Med & Cardiol, Akita, Japan
[9] Akita Univ, Dept Life Sci, Grad Sch Engn Sci, Akita, Japan
关键词
Antineutrophil cytoplasmic antibody-associated glomerulonephritis; Japanese cohort; Prognosis; Renal risk score; Validation study; ANTIBODY-ASSOCIATED VASCULITIS; HISTOPATHOLOGICAL CLASSIFICATION; BIOPSY;
D O I
10.1007/s10157-022-02217-w
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background We determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) and high myeloperoxidase (MPO)-ANCA positivity; these aspects remain to be verified. Methods This retrospective study was conducted on 86 Japanese patients with new, biopsy-confirmed AAGN. We calculated the RRS and analyzed the relationship between this classification, and clinicopathological features and prognosis. We also compared the predictive values between RRS for endpoints including renal death and conventional prognostic tools for patients with AAGN. Results There were 33, 37, and 16 patients in the low-, medium-, and high-risk groups, respectively. All patients were MPO-ANCA positive. The median follow-up period was 33 months; 16 (18.6%) patients progressed to end-stage renal disease (ESRD). In the high-risk group, 9/16 (56.3%) patients progressed to ESRD, and renal prognosis was significantly poorer than that in other groups (low-risk group, P < 0.001; medium-risk group, P = 0.004). In Cox multivariate regression analysis, RRS was an independent, poor renal prognostic factor (hazard ratio 5.22; 95% confidence interval 2.20-12.40; P < 0.001). The receiver-operating characteristic curves of the RRS for each endpoint were comparable with those of the 2010 histological classification and those of the severity classification of Japanese rapidly progressive glomerulonephritis. Conclusions This is the first study to report the usefulness of the RRS for predicting renal outcomes among Japanese patients with AAGN. Our predictive value of the RRS was comparable with that of conventional prognostic tools.
引用
收藏
页码:760 / 769
页数:10
相关论文
共 27 条
  • [1] An Xiao-Ning, 2021, Clin Exp Rheumatol, V39 Suppl 129, P39, DOI 10.55563/clinexprheumatol/24ep0c
  • [2] Kidney biopsy as a predictor for renal outcome in ANCA-associated necrotizing glomerulonephritis
    Bajema, IM
    Hagen, EC
    Hermans, J
    Noël, LH
    Waldherr, R
    Ferrario, F
    van der Woude, FJ
    Bruijn, JA
    [J]. KIDNEY INTERNATIONAL, 1999, 56 (05) : 1751 - 1758
  • [3] Histopathologic Classification of ANCA-Associated Glomerulonephritis
    Berden, Annelies E.
    Ferrario, Franco
    Hagen, E. Christiaan
    Jayne, David R.
    Jennette, J. Charles
    Joh, Kensuke
    Neumann, Irmgard
    Noel, Laure-Helene
    Pusey, Charles D.
    Waldherr, Ruediger
    Bruijn, Jan A.
    Bajema, Ingeborg M.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (10): : 1628 - 1636
  • [4] Development and validation of a renal risk score in ANCA-associated glomerulonephritis
    Brix, Silke R.
    Noriega, Mercedes
    Tennstedt, Pierre
    Vettorazzi, Eik
    Busch, Martin
    Nitschke, Martin
    Jabs, Wolfram J.
    Oezcan, Fedai
    Wendt, Ralph
    Hausberg, Martin
    Sellin, Lorenz
    Panzer, Ulf
    Huber, Tobias B.
    Waldherr, Ruediger
    Hopfer, Helmut
    Stahl, Rolf A. K.
    Wiech, Thorsten
    [J]. KIDNEY INTERNATIONAL, 2018, 94 (06) : 1177 - 1188
  • [5] Renal Survival in Proteinase 3 and Myeloperoxidase ANCA-Associated Systemic Vasculitis
    de Joode, Anoek A. E.
    Sanders, Jan Stephan F.
    Stegeman, Coen A.
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (10): : 1709 - 1717
  • [6] Antineutrophil cytoplasm antibody-associated vasculitis: recent developments
    Furuta, Shunsuke
    Jayne, David R. W.
    [J]. KIDNEY INTERNATIONAL, 2013, 84 (02) : 244 - 249
  • [7] Renal histology in ANCA-associated vasculitis:: Differences between diagnostic and serologic subgroups
    Hauer, HA
    Bajema, IM
    van Houwelingen, HC
    Ferrario, F
    Noël, LH
    Waldherr, R
    Jayne, DRW
    Rasmussen, N
    Bruijn, JA
    Hagen, EC
    [J]. KIDNEY INTERNATIONAL, 2002, 61 (01) : 80 - 89
  • [8] Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis
    Hilhorst, Marc
    van Paassen, Pieter
    Tervaert, Jan Willem Cohen
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (10): : 2314 - 2327
  • [9] Clinical and histological features of lupus nephritis in Japan: A cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)
    Hiromura, Keiju
    Ikeuchi, Hidekazu
    Kayakabe, Ken
    Sugiyama, Hitoshi
    Nagata, Michio
    Sato, Hiroshi
    Yokoyama, Hitoshi
    Nojima, Yoshihisa
    [J]. NEPHROLOGY, 2017, 22 (11) : 885 - 891
  • [10] Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study
    Hong, Yan
    Shi, Pengxian
    Liu, Xia
    Yang, Liu
    Li, Kang
    Xu, Feng
    Liang, Shaoshan
    Liu, Zhengzhao
    Zhang, Haitao
    Chen, Yinghua
    Hu, Weixin
    [J]. CLINICAL RHEUMATOLOGY, 2019, 38 (06) : 1665 - 1673