Design and Synthesis of 3′-Fluoropenciclovir Analogues as Antiviral Agents

被引：3

作者：

Choi, Myung-Hee ^{[1
]}

Lee, Chong-Kyo ^{[2
]}

Kim, Hee-Doo ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[2] Res Inst Chem Technol, Taejon 305606, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 02期

关键词：

Antiviral; Fluorine switch; Penciclovir; 3 '-Fluoropenciclovir; OPEN-CHAIN ANALOGS; NUCLEOSIDES; NEPLANOCIN;

D O I：

10.1007/s12272-010-0202-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.

引用

页码：197 / 202

页数：6

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