Association between hyperhomocysteinemia and primary pulmonary hypertension

被引：18
作者：
Arroliga, AC
Sandur, S
Jacobsen, DW
Tewari, S
Mustafa, M
Mascha, EJ
Robinson, K
机构：
[1] Cleveland Clin Fdn, Dept Pulm & Crit Care Med, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Cell Biol, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Dept Biostat, Cleveland, OH 44195 USA
[4] Case Western Reserve Univ, Dept Pulm & Crit Care Med, Cleveland, OH 44106 USA
[5] Wake Forest Univ, Dept Med & Cardiol, Winston Salem, NC 27109 USA
来源：
RESPIRATORY MEDICINE | 2003年 / 97卷 / 07期
关键词：
hyperhomocysteinemia; primary pulmonary hypertension;
D O I：
10.1016/S0954-6111(03)00038-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Study objective: This case-control study was conducted to test the hypothesis that fasting homocysteine levels are higher in PPH patients than in healthy controls. Design: Levels of plasma total homocysteine, serum folate, vitamin B-12, and serum creatinine in 18 consecutive patients with PPH were compared with data from 36 age- and sex-matched controls. Results: Eight of the 18 patients (44.4%) and three of the 36 controls (8.3%) had elevated plasma total homocysteine (tHcy) levels (greater than or equal to 15 mumol/l, odds ratio 8.8; 95% CI: 2.0-39.6; P = 0.005). There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P = 0.036). Conclusion: PPH patients are significantly more likely to have hyperhomocysteinemia, and higher mean plasma total homocysteine levels than in controls. Plasma total homocysteine may be an important factor in the pathogenesis of PPH. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：825 / 829
页数：5
相关论文
共 21 条
[1]   LIPID-PEROXIDATION AND SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN TO IN-VITRO OXIDATION IN HYPERHOMOCYSTEINAEMIA [J].
BLOM, HJ ;
KLEINVELD, HA ;
BOERS, GHJ ;
DEMACKER, PNM ;
HAKLEMMERS, HLM ;
POELEPOTHOFF, MTWBT ;
TRIJBELS, JMF .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1995, 25 (03) :149-154
[2]   Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia - An effect reversible with vitamin C therapy [J].
Chambers, JC ;
McGregor, A ;
Jean-Marie, J ;
Obeid, OA ;
Kooner, JS .
CIRCULATION, 1999, 99 (09) :1156-1160
[3]   Hyperhomocysteinemia as a risk factor for deep-vein thrombosis [J].
denHeijer, M ;
Koster, T ;
Blom, HJ ;
Bos, GMJ ;
Briet, E ;
Reitsma, PH ;
Vandenbroucke, JP ;
Rosendaal, FR .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (12) :759-762
[4]   PREDICTING GLOMERULAR FUNCTION FROM ADJUSTED SERUM CREATININE [J].
GAULT, MH ;
LONGERICH, LL ;
HARNETT, JD ;
WESOLOWSKI, C .
NEPHRON, 1992, 62 (03) :249-256
[5]  
JACOBSEN DW, 1994, CLIN CHEM, V40, P873
[6]   Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans [J].
Kanani, PM ;
Sinkey, CA ;
Browning, RL ;
Allaman, M ;
Knapp, HR ;
Haynes, WG .
CIRCULATION, 1999, 100 (11) :1161-1168
[7]   Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension [J].
Kaneko, FT ;
Arroliga, AC ;
Dweik, RA ;
Comhair, SA ;
Laskowski, D ;
Oppedisano, R ;
Thomassen, MJ ;
Erzurum, SC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (03) :917-923
[8]  
Lentz S R, 1998, Curr Opin Hematol, V5, P343, DOI 10.1097/00062752-199809000-00007
[9]   Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins [J].
Nappo, F ;
De Rosa, N ;
Marfella, R ;
De Lucia, D ;
Ingrosso, D ;
Perna, AF ;
Farzati, B ;
Giugliano, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (22) :2113-2118
[10]   Homocysteine and cardiovascular disease [J].
Refsum, H ;
Ueland, PM ;
Nygård, O ;
Vollset, SE .
ANNUAL REVIEW OF MEDICINE, 1998, 49 :31-62
123