Wilson disease: copper deficiency and iatrogenic neurological complications with zinc therapy

被引:7
作者
Wu, Landy M. [1 ]
Ekladious, Adel [2 ]
Wheeler, Luke [3 ,4 ]
Mohamad, Abdulrazak A. [5 ]
机构
[1] Frankston Hosp, Dept Med, Melbourne, Vic, Australia
[2] Bunbury Hosp, Dept Med, Bunbury, Australia
[3] Univ Notre Dame, Fremantle, WA, Australia
[4] Northern Adelaide Local Hlth Unit, Dept Med, Adelaide, SA, Australia
[5] Hunter New England Area Hlth, Dept Med, Newcastle, NSW, Australia
关键词
Wilson disease; zinc; copper; subacute combined degeneration; neurological complication; HYPOCUPREMIA; MYELOPATHY;
D O I
10.1111/imj.14694
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 17-year-old female was diagnosed with Wilson disease and commenced on oral zinc therapy. She re-presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc-induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc-induced copper deficiency and stringent follow-up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits.
引用
收藏
页码:121 / 123
页数:3
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