Wilson disease: copper deficiency and iatrogenic neurological complications with zinc therapy

被引：7

作者：

Wu, Landy M. ^{[1
]}

Ekladious, Adel ^{[2
]}

Wheeler, Luke ^{[3
,4
]}

Mohamad, Abdulrazak A. ^{[5
]}

机构：

[1] Frankston Hosp, Dept Med, Melbourne, Vic, Australia

[2] Bunbury Hosp, Dept Med, Bunbury, Australia

[3] Univ Notre Dame, Fremantle, WA, Australia

[4] Northern Adelaide Local Hlth Unit, Dept Med, Adelaide, SA, Australia

[5] Hunter New England Area Hlth, Dept Med, Newcastle, NSW, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2020年 / 50卷 / 01期

关键词：

Wilson disease; zinc; copper; subacute combined degeneration; neurological complication; HYPOCUPREMIA; MYELOPATHY;

D O I：

10.1111/imj.14694

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 17-year-old female was diagnosed with Wilson disease and commenced on oral zinc therapy. She re-presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc-induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc-induced copper deficiency and stringent follow-up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits.

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收藏

页码：121 / 123

页数：3

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