Changes in Body Composition Over 8 Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study

被引：60

作者：

Pownall, Henry J. ^{[1
,2
]}

Bray, George A. ^{[3
]}

Wagenknecht, Lynne E. ^{[4
]}

Walkup, Michael P. ^{[5
]}

Heshka, Stanley ^{[6
]}

Hubbard, Van S. ^{[7
]}

Hill, James ^{[8
]}

Kahn, Steven E. ^{[9
,10
]}

Nathan, David M. ^{[11
]}

Schwartz, Anne V. ^{[12
]}

Johnson, Karen C. ^{[13
]}

机构：

[1] Houston Methodist Res Inst, Div Atherosclerosis, Dept Cardiol, Houston, TX USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Pennington Biomed Res Ctr, Div Clin Obes, Baton Rouge, LA 70808 USA

[4] Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27157 USA

[5] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[6] St Lukes Roosevelt Hosp, Dept Med, New York, NY 10025 USA

[7] NIH, Bethesda, MD 20892 USA

[8] Univ Colorado, Anschutz Hlth & Wellness Ctr, Denver, CO 80202 USA

[9] VA Puget Sound Hlth Care Syst, Div Metab Endocrinol & Nutr, Dept Med, Seattle, WA USA

[10] Univ Washington, Seattle, WA 98195 USA

[11] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[12] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[13] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA

来源：

OBESITY | 2015年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TYPE-2; DIABETES-MELLITUS; X-RAY ABSORPTIOMETRY; DISEASE RISK-FACTORS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; FAT DISTRIBUTION; GENERAL-POPULATION; INSULIN-RESISTANCE; OLDER-ADULTS; OBESE WOMEN;

D O I：

10.1002/oby.21005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveTo determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. MethodsBody composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain 7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. ResultsAt 1 year, the intervention group lost fat (5.60.2 kg) and lean mass (2.3 +/- 0.1 kg) but regained fat (approximate to 100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 +/- 0.4 vs. 2.3 +/- 0.4 kg); comparison group weight loss was mostly lean mass (2.1 +/- 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. ConclusionsReduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

引用

页码：565 / 572

页数：8

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