Synthesis of Isoquinoline from Benzimidates via Ru(II)-Catalyzed C-H Alkylation/Annulations with Diazo Compounds

被引：12

作者：

Borah, Gongutri ^{[1
]}

Ramaiah, Danaboyina ^{[1
]}

Patel, Pitambar ^{[1
]}

机构：

[1] CSIR, Chem Sci & Technol Div, North East Inst Sci & Technol, Jorhat 785006, Assam, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 37期

关键词：

C-H annulation; benzimidate; diazo compounds; isoquinoline; ruthenium catalysis; ALPHA-DIAZOCARBONYL COMPOUNDS; BISCHLER-NAPIERALSKI REACTION; CARBENE MIGRATORY INSERTION; BETA-PHENYLETHYLAMINES; ASYMMETRIC-SYNTHESIS; CARBONYL-COMPOUNDS; DIRECTING GROUPS; BOND ACTIVATION; FUNCTIONALIZATION; ANNULATION;

D O I：

10.1002/slct.201802831

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Ru(II)-catalyzed C-H alkylation/annulations of benzimidate with diazo compounds have been developed for the synthesis of functionalized isoquinoline. The reaction proceeds under mild condition and exhibit broad functional group tolerance. This strategy also provides a direct approach to isoquinolines and 3,4-dihydrophenanthridin synthesis. Moreover, Ru(II)-catalyzed C-H carbenoid functionalization of benzimidate with diazodiester is also demonstrated.

引用

页码：10333 / 10337

页数：5

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