In vivo biocompatibility studies of nano TiO2 materials

被引：21
作者：
Han, Wei [1 ]
Wang, Yuedan [2 ]
Zheng, Yufeng [1 ,3 ]
机构：
[1] Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China
[2] Peking Univ, Sch Basic Med, Dept Immunol, Beijing 100083, Peoples R China
[3] Peking Univ, State Key Lab Turbulence & Complex Syst, Coll Engn, Beijing 100871, Peoples R China
来源：
MULTI-FUNCTIONAL MATERIALS AND STRUCTURES II, PTS 1 AND 2 | 2009年 / 79-82卷
关键词：
TiO2; nanomaterials; in vivo; biocompatibility; morphology; oxidative stress level; PARTICLES; TOXICITY; MICE;
D O I：
10.4028/www.scientific.net/AMR.79-82.389
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
TiO2 nanomaterials with different dimensions(zero and one), sizes(20nm, 50nm and 100nm in diameter) and crystal structures(100% rutile, 100% anatase and combination of 20% rutile and 80% anatase) were confected to suspensions and ointment with varied concentrations and evaluated in animal model (Balb-c mouse). These mouse were divided into various groups randomly, with suspension intraperitoneally injected or ointment transdermally daubed. Heart, lung, liver and kidney were collected and prepared to HE sample after one week. Spectrophotometry was applied to study total antioxide capability and catalase activity of blood and tissues. It has been shown that all TiO2 nanomaterial groups had no effect on lives' morphology and oxidative stress, with no obvious histopathological changes observed in heart, lung, liver and kidney, and these tissues presented no vacuolar degeneration, necrosis edema, engorgement and inflammation.
引用
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页码：389 / +
页数：2
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