31P-MR spectroscopy in children and adolescents with a familial risk of schizophrenia

被引:14
作者
Rzanny, R
Klemm, S
Reichenbach, JR
Pfleiderer, SOR
Schmidt, B
Volz, HP
Blanz, B
Kaiser, WA
机构
[1] Univ Jena, Klinikum, Abt MT, Inst Diagnost & Intervent Radiol, D-07741 Jena, Germany
[2] Univ Jena, Klinikum, Psychiat Klin, D-07741 Jena, Germany
[3] Univ Jena, Klinikum, Kinder & Jugendpsychiat Klin, D-07741 Jena, Germany
关键词
31P-MR spectroscopy; schizophrenia; adolescence;
D O I
10.1007/s00330-002-1565-1
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Based on a previous report [9] on alterations of membrane phosphorus metabolism in asymptomatic family members of schizophrenic patients, the aim of the present study was to extend and improve the evaluation and data processing of P-31 spectroscopic data obtained from a larger study population by including an analysis of the broad spectral component (BC) of membrane phospholipids (PL). Eighteen children and siblings of patients with schizophrenia and a gender and age-matched control group of 18 healthy subjects without familial schizophrenia were investigated with phosphorus magnetic resonance spectroscopy (P-31-MRS) by using image selected in vivo spectroscopy (ISIS) in the dorsolateral prefrontal regions (DLPFR) of the brain. Spectral analysis was performed by using both the full and truncated FID to estimate metabolic peak ratios of different P-31 metabolites and the intensity and linewidth of the broad component. A significantly higher PDE level (p<0.01) and increased linewidth of the PDE components were observed for the high-risk group compared with the control group (p=0.02). No significant differences were observed for PME as well as for other P-31-metabolites. No differences were observed between the left and right hemispheres for different normalised P-31-metabolic levels. Decreased intensities (p=0.03) and smaller linewidths (p=0.01) were obtained for the broad component in the high-risk group. Impairments of membrane metabolism that are typical for schizophrenic patients are partially observed in adolescent asymptomatic family members of schizophrenics, including increased levels of low molecular PDE compounds indicating increased membrane degradation processes, no changes for PME, and decreased intensities and linewidths of the BC indicating changes in the composition and fluidity of membrane phospholipids. Despite limitations to completely suppress fast-relaxing components by dismissing initial FID data points, the spectroscopic results indicate additional changes in the membrane metabolism of high-risk subjects beyond changes of synthesis and degradation.
引用
收藏
页码:763 / 770
页数:8
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