Anxiety-associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product

被引：33

作者：

Dias Castro, Tassia Flavia ^{[1
]}

da Silva Souza, Jose Gilmar ^{[2
]}

Souza de Carvalho, Aline Ferreira ^{[1
]}

Assis, Isadora de Lima ^{[1
]}

Palmieri, Marcel Jose ^{[3
]}

Andrade Vieira, Larissa Fonseca ^{[3
]}

Marcussi, Silvana ^{[4
]}

Ferreira Machado, Monica Rodrigues ^{[5
]}

Solis Murgas, Luis David ^{[1
]}

机构：

[1] Univ Fed Lavras, Physiol & Pharmacol Sect, Dept Vet Med, CP 3037, BR-37200000 Lavras, MG, Brazil

[2] Univ Fed Lavras, Dept Anim Sci, CP 3037, BR-37200000 Lavras, MG, Brazil

[3] Univ Fed Lavras, Dept Biol Sci, CP 3037, BR-37200000 Lavras, MG, Brazil

[4] Univ Fed Lavras, Dept Chem, CP 3037, BR-37200000 Lavras, MG, Brazil

[5] Univ Fed Goias, Dept Biol Sci, Campus Univ City,BR 364,Km 195,3800, BR-75801615 Jatai, Go, Brazil

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2018年 / 62卷

关键词：

Triazole; Comet assay; Micronucleus test; MICRONUCLEUS TEST; COMET ASSAY; DNA-DAMAGE; PROCHILODUS-LINEATUS; TRIAZOLE FUNGICIDES; IN-VIVO; ZEBRAFISH; TOXICITY; WATER; ERYTHROCYTES;

D O I：

10.1016/j.etap.2018.06.011

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eight tanks and exposed to concentrations of 0; 100; 200 and 300 mu g/L the commercial product based on tebuconazole, with their respective replicates at 24, 72 and 96 h. The results showed a behavioral deviation of zebrafish and a significant (p < 0.05) increase in DNA damage as a function of exposed time and different concentrations of the commercial product in relation to the negative control. The results obtained in this study allow to conclude that tebuconazole has effects on adults of Danio rerio, inducing geno-toxicity and mutagenicity, as well as altering neurological functions related to the change in the behavior of adults.

引用

页码：140 / 146

页数：7

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