Zinc(II)-induced control of the internalization of a near-infrared fluorescent probe by live cells

被引:7
作者
Koenig, Sandra G. [1 ]
Oez, Simin [1 ]
Kraemer, Roland [1 ]
机构
[1] Heidelberg Univ, Anorgan Chem Inst, Neuenheimer Feld 270, D-69120 Heidelberg, Germany
关键词
PANCREATIC BETA-CELLS; ZINC; CANCER; LOCALIZATION;
D O I
10.1039/c6mb00105j
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We describe zinc-promoted cellular uptake of a near-infrared fluorophore modified with a terpyridine ligand. In response to varying concentrations of exogenous zinc(II), we observed increasing cellular uptake in live HeLa cells as well as other cell lines, whereas only negligible staining was detected in the absence of zinc(II).
引用
收藏
页码:1114 / 1117
页数:4
相关论文
共 34 条
[1]   Zinc: The Brain's Dark Horse [J].
Bitanihirwe, Byron K. Y. ;
Cunningham, Miles G. .
SYNAPSE, 2009, 63 (11) :1029-1049
[2]   The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots [J].
Costello, Leslie C. ;
Franklin, Renty B. .
MOLECULAR CANCER, 2006, 5 (1)
[3]   The neurobiology of zinc in health and disease [J].
Frederickson, CJ ;
Koh, JY ;
Bush, AI .
NATURE REVIEWS NEUROSCIENCE, 2005, 6 (06) :449-462
[4]   Importance of zinc in the central nervous system: The zinc-containing neuron [J].
Frederickson, CJ ;
Suh, SW ;
Silva, D ;
Frederickson, CJ ;
Thompson, RB .
JOURNAL OF NUTRITION, 2000, 130 (05) :1471S-1483S
[5]   Cellular uptake of PNA -: Terpyridine conjugates and its enhancement by Zn2+ ions [J].
Fuessl, Andreas ;
Schleifenbaum, Andreas ;
Goeritz, Mareike ;
Riddell, Andrew ;
Schultz, Carsten ;
Kraemer, Roland .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (18) :5986-5987
[6]   Allosteric control of oligonucleotide hybridization by metal-induced cyclization [J].
Göritz, M ;
Krämer, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (51) :18016-18017
[7]  
Graf N., 2006, THESIS RUPRECHT KARL
[8]   Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis [J].
Gumulec, Jaromir ;
Masarik, Michal ;
Adam, Vojtech ;
Eckschlager, Tomas ;
Provaznik, Ivo ;
Kizek, Rene .
PLOS ONE, 2014, 9 (06)
[9]   EXCHANGE STUDIES OF CERTAIN CHELATE COMPOUNDS OF TRANSITIONAL METALS .8. 2,2',2''-TERPYRIDINE COMPLEXES [J].
HOGG, R ;
WILKINS, RG .
JOURNAL OF THE CHEMICAL SOCIETY, 1962, (JAN) :341-&
[10]  
Hogstrand C, 2014, RSC METALLOBIO SER, V2, P666