Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

被引：350

作者：

Sun, Qihang ^{[1
,2
,3
]}

Sun, Xuanrong ^{[1
,2
]}

Ma, Xinpeng ^{[3
]}

Zhou, Zhuxian ^{[3
]}

Jin, Erlei ^{[3
]}

Zhang, Bo ^{[3
]}

Shen, Youqing ^{[1
,2
]}

Van Kirk, Edward A. ^{[4
]}

Murdoch, William J. ^{[4
]}

Lott, Joseph R. ^{[5
]}

Lodge, Timothy P. ^{[5
]}

Radosz, Maciej ^{[3
]}

Zhao, Yuliang ^{[1
,2
,6
]}

机构：

[1] Zhejiang Univ, Dept Chem & Biol Engn, Minist Educ, Ctr Bionanoengn, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Dept Chem & Biol Engn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Peoples R China

[3] Univ Wyoming, Dept Chem Engn, Laramie, WY 82071 USA

[4] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA

[5] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[6] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 45期

关键词：

POLYMERIC NANOPARTICLES; GENE DELIVERY; PENETRATION; TUMORS; PH; CLEARANCE; MICELLES; SYSTEMS; NANOTECHNOLOGY; DENDRIMERS;

D O I：

10.1002/adma.201401554

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented). © 2014 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7615 / 7621

页数：7

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