Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers

被引：5
作者：
Han, Sevtap [1 ]
Aydin, Muammer Merve [2 ]
Akansel, Serdar [3 ]
Usanmaz, Suzan Emel [3 ]
Akcali, Can [2 ]
Uludag, Mecit Orhan [1 ]
Yilmaz, Emine Demirel [3 ]
机构：
[1] Gazi Univ, Dept Pharmacol, Fac Pharm, Ankara, Turkey
[2] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey
[3] Ankara Univ, Fac Med, Dept Med Pharmacol, Ankara, Turkey
来源：
TURKISH JOURNAL OF BIOLOGY | 2018年 / 42卷 / 04期
关键词：
Aging; endothelial function; biomarker; histone methylation; NITRIC-OXIDE SYNTHASE; ENDOGENOUS HYDROGEN-SULFIDE; ASYMMETRIC DIMETHYLARGININE ADMA; OXIDATIVE STRESS; SMOOTH-MUSCLE; MESENTERIC-ARTERIES; HISTONE METHYLATION; GENDER DIFFERENCES; BLOOD-PRESSURE; CA2+ ENTRY;
D O I：
10.3906/biy-1803-59
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner. Acetylcholine (ACh)-induced relaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats. In males, maximum relaxations related to ACh were higher in 1- and 6-month-old rats than in 3- and 12-month-old rats. Plasma levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) decreased with age in female rats, and total antioxidant capacity (TAG) and hydrogen sulfide (H2S) levels displayed biphasic alterations. In male rats, plasma levels of NO, TAG, and ADMA decreased with age, and H2S levels increased. Aging also caused a sex-dependent alteration in epigenetic modification of vessels. Expressions of H3K27me2, H3K27me3, H3K36me2, and H3K36me3 were much higher in vessels of 12-month-old female rats compared to those in younger age groups. These results indicate that vascular functions, epigenetic modifications of vessels, and plasma levels of endothelium-related biomarkers are affected by age and sex. These findings could be important for the assessment of vascular status over the course of the life span.
引用
收藏
页码：286 / 296
页数：11
相关论文
共 80 条
[1]   Aging Enhances Autonomic Support of Blood Pressure in Women [J].
Barnes, Jill N. ;
Hart, Emma C. ;
Curry, Timothy B. ;
Nicholson, Wayne T. ;
Eisenach, John H. ;
Wallin, B. Gunnar ;
Charkoudian, Nisha ;
Joyner, Michael J. .
HYPERTENSION, 2014, 63 (02) :303-308
[2]   Aging alters mechanical and contractile properties of the Fisher 344/Nnia X Norway/Binia rat aorta [J].
Blough, E. R. ;
Rice, K. M. ;
Desai, D. H. ;
Wehner, P. ;
Wright, G. L. .
BIOGERONTOLOGY, 2007, 8 (03) :303-313
[3]   Asymmetric Dimethylarginine (ADMA): A Promising Biomarker for Cardiovascular Disease? [J].
Bouras, Georgios ;
Deftereos, Spyridon ;
Tousoulis, Dimitrios ;
Giannopoulos, Georgios ;
Chatzis, Georgios ;
Tsounis, Dimitrios ;
Cleman, Michael W. ;
Stefanadis, Christodoulos .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (02) :180-200
[4]   Epigenetics of Aging and Aging-related Disease [J].
Brunet, Anne ;
Berger, Shelley L. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2014, 69 :S17-S20
[5]   AGING IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN HEALTHY-MEN YEARS BEFORE THE AGE-RELATED DECLINE IN WOMEN [J].
CELERMAJER, DS ;
SORENSEN, KE ;
SPIEGELHALTER, DJ ;
GEORGAKOPOULOS, D ;
ROBINSON, J ;
DEANFIELD, JE .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 24 (02) :471-476
[6]   Aging-associated endothelial dysfunction in humans is reversed by L-arginine [J].
Chauhan, A ;
More, RS ;
Mullins, PA ;
Taylor, G ;
Petch, MC ;
Schofield, PM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (07) :1796-1804
[7]   Endogenous hydrogen sulfide in patients with COPD [J].
Chen, YH ;
Yao, WZ ;
Geng, B ;
Ding, YL ;
Lu, M ;
Zhao, MW ;
Tang, CS .
CHEST, 2005, 128 (05) :3205-3211
[8]   Alterations of nitric oxide synthase expression with aging and hypertension in rats [J].
Chou, TC ;
Yen, MH ;
Li, CY ;
Ding, YA .
HYPERTENSION, 1998, 31 (02) :643-648
[9]   Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation [J].
Coletta, Ciro ;
Papapetropoulos, Andreas ;
Erdelyi, Katalin ;
Olah, Gabor ;
Modis, Katalin ;
Panopoulos, Panagiotis ;
Asimakopoulou, Antonia ;
Geroe, Domokos ;
Sharina, Iraida ;
Martin, Emil ;
Szabo, Csaba .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (23) :9161-9166
[10]   Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones [J].
Crews, JK ;
Khalil, RA .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1999, 26 (09) :707-715
12345678