Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

被引：7
|
作者：
Son, KH [1 ]
Hong, SH [1 ]
Kwon, YK [1 ]
Bae, KS [1 ]
Kim, YK [1 ]
Kwon, BM [1 ]
Kim, SU [1 ]
Bok, SH [1 ]
机构：
[1] KIST, KRIBB, Taejon 305600, South Korea
来源：
BIOTECHNOLOGY LETTERS | 1998年 / 20卷 / 02期
关键词：
D O I：
10.1023/A:1005324407319
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.
引用
收藏
页码：149 / 151
页数：3
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