Biotransformation of paclitaxel (Taxol®) by the cell suspension cultures of Rauwolfia serpentina

被引：0

作者：

Zhao, Y

Yu, RM ^{[1
]}

Schroeder, C

Sadler, I

Unger, M

Sun, XF

Rankin, DWH

Stöckigt, J

机构：

[1] Jinan Univ, Coll Pharm, Guangzhou 510632, Peoples R China

[2] Zhejiang Univ, Dep Tradit Chinese Med & Nat Drug Res, Coll Pharmaceut Sci, Hangzhou 310031, Peoples R China

[3] Univ Mainz, Lehrstuhl Pharmazeut Biol, Inst Pharm, D-55099 Mainz, Germany

[4] Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

ACTA BOTANICA SINICA | 2004年 / 46卷 / 11期

关键词：

biotransformation; cell culture; paclitaxel; taxanes; Rauwolfia serpentina;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biotransformation of paclitaxel (Taxol(R)) by the cell suspension cultures of Rauwolfia serpentina (L.) Benth. et Kurz. were investigated. Three Paclitaxel-based intracellular metabolites were detected from the cell filter cake and were, by high field H-1-NMR and MS data, identified as 10-deacetyltaxol, baccatin III, and 10-deacetylbaccatin III. No glucosidated or hydroxylated derivatives were checked out in this incubation experiment.

引用

页码：1383 / 1386

页数：4

共 33 条

[1] DOCETAXEL (TAXOTERE(R)) - A REVIEW OF PRECLINICAL AND CLINICAL-EXPERIENCE .1. PRECLINICAL EXPERIENCE [J].