Serum IGF-I and IGFBP-3 Reference Values from a Chemiluminescent Assay in Normal Children and Adolescents of Hispanic and Italian Origin: Presence of Sexual Dimorphism in IGF-I Values

被引：0
作者：
Chaler, E. A. [1 ]
Meazza, C. [2 ]
Guercio, G. [1 ]
Maceiras, M. [1 ]
Rivarola, M. A. [1 ]
Laarej, K. [2 ]
Pagani, S. [2 ]
Areny, G. [1 ]
Albertini, R. [3 ]
Llinares, V. [1 ]
Belgorosky, A. [1 ]
Bozzola, M. [2 ]
机构：
[1] Garrahan Pediat Hosp, Endocrinol Lab, Buenos Aires, DF, Argentina
[2] Univ Pavia, Dept Pediat, I-27100 Pavia, Italy
[3] IRCCS San Matteo Fdn, Clin Chem Lab, Pavia, Italy
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2009年 / 22卷 / 12期
关键词：
IGF-I; IGFBP-3; chemiluminescent assay; reference ranges; sexual dimorphism; GROWTH-FACTOR-I; BINDING PROTEIN-3 CONCENTRATIONS; BODY-MASS INDEX; INSULIN SENSITIVITY; ADRENAL ANDROGENS; REFERENCE RANGES; CHILDHOOD; AGE; PUBERTY; AXIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Serum IGF-I and IGFBP-3 assays are used to monitor rhGH treatment. Some discrepancies in results obtained by means of different assays have been reported. The aim of this study was to establish normal ranges for circulating IGF-I and IGFBP-3 in children and adolescents of Hispanic and Italian origin. Circulating levels of IGF-I and IGFBP-3 were measured in 169 Hispanic and Italian prepubertal children and 66 adolescents of both sexes, using a chemiluminescent assay. Serum levels of IGF-I and IGFBP-3 increased from early childhood into adolescence. After pubertal peaks of IGF-I and IGFBP-3, slight decreases were observed with increasing age. Furthermore, serum IGF-I levels were significantly higher in girls than in boys, suggesting a sexual dimorphism in serum IGF-I values in late prepuberty and early puberty. Differences in IGF-I and IGFBP-3 absolute values between our study and previous studies suggest the need to establish reference ranges for each ethnic group.
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页码：1127 / 1135
页数：9
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