A Diatomic Molecule Receptor That Removes CO in a Living Organism

被引：58

作者：

Kitagishi, Hiroaki ^{[1
]}

Negi, Shigeru ^{[2
]}

Kiriyama, Akiko ^{[2
]}

Honbo, Akino ^{[2
]}

Sugiura, Yukio ^{[2
]}

Kawaguchi, Akira T. ^{[3
]}

Kano, Koji ^{[1
]}

机构：

[1] Doshisha Univ, Dept Chem & Biochem, Kyoto 6100321, Japan

[2] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Kyoto 6100395, Japan

[3] Tokai Univ, Sch Med, Kanagawa 2591193, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 07期

关键词：

carbon monoxide; cyclodextrins; in vivo experiments; porphyrinoids; supramolecular chemistry; AQUEOUS-SOLUTION; CARBON-MONOXIDE; MYOGLOBIN; COMPLEXES; MODEL; HYDROLYSIS; PORPHYRIN; ENZYMES;

D O I：

10.1002/anie.200906149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A CO stripper: The O2-bound form of an iron(II) porphyrin cyclodextrin supramolecular complex (hemoCD) infused into a rat vein reacted with internal CO through ligand exchange, and the CO-bound hemoCD was immediately excreted in the urine (see picture). The hemoCD acting as a CO receptor made it possible to quantify endogenous CO in a living organism. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1312 / 1315

页数：4

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