Impact of prior vaccination with Covishield™ and Covaxin® on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study

被引：16

作者：

Abhilash, Kundavaram Paul Prabhakar ^{[1
]}

Mathiyalagan, Ponnivalavan ^{[1
]}

Krishnaraj, Vivek Raja K. ^{[1
]}

Selvan, Saravanan ^{[1
]}

Kanagarajan, Rohini ^{[1
]}

Reddy, Narmadha P. ^{[1
]}

Rajendiran, Natarajan ^{[1
]}

Hazra, Darpanarayan ^{[1
]}

Gunasekaran, Karthik ^{[2
]}

Moorthy, Mahesh ^{[3
]}

Jasmine, Sudha ^{[2
]}

Davis, John Prasad ^{[2
]}

George, Tina ^{[2
]}

George, Krupa ^{[2
]}

Varghese, George M. ^{[4
]}

Rupali, Priscilla ^{[4
]}

Isaac, T. J. Barney ^{[5
]}

Gupta, Richa ^{[5
]}

Pichamuthu, Kishore ^{[6
]}

Joy, Melvin ^{[7
]}

Jayaseelan, Lakshmanan ^{[7
]}

Mathews, Prasad ^{[8
]}

Peter, John Victor ^{[9
]}

机构：

[1] Christian Med Coll & Hosp, Dept Emergency Med, Vellore 632004, Tamil Nadu, India

[2] Christian Med Coll & Hosp, Dept Gen Med, Vellore 632004, Tamil Nadu, India

[3] Christian Med Coll & Hosp, Dept Clin Virol, Vellore, Tamil Nadu, India

[4] Christian Med Coll & Hosp, Dept Infect Dis, Vellore 632004, Tamil Nadu, India

[5] Christian Med Coll & Hosp, Dept Pulm Med, Vellore, Tamil Nadu, India

[6] Christian Med Coll & Hosp, Div Crit Care, Med Intens Care Unit, Vellore 632004, Tamil Nadu, India

[7] Christian Med Coll & Hosp, Dept Biostat, Vellore, Tamil Nadu, India

[8] Christian Med Coll & Hosp, Dept Geriatr Med, Med Superintendent, Vellore, Tamil Nadu, India

[9] Christian Med Coll & Hosp, Dept Crit Care, Vellore, Tamil Nadu, India

来源：

VACCINE | 2022年 / 40卷 / 13期

关键词：

COVID-19; Vaccination; Corona virus; Covishiele; Covaxin (R); Mortality; POPULATION; SEPSIS;

D O I：

10.1016/j.vaccine.2022.02.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: COVID-19 vaccines were authorised for emergency use to mitigate the impact of the pandemic. This study evaluated the effect of prior vaccination with either Oxford Astra Zeneca's Covishield (TM) or Bharath Biotech's Covaxin (R) on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in India. Methodology: In this cohort study comprising of RT-PCR confirmed symptomatic COVID-19 patients presenting during April and May 2021, the effect of prior vaccination on mortality (primary outcome), need for hospitalization, oxygen therapy, non-invasive ventilation (NIV) and intensive care unit (ICU) admission were assessed and expressed as risk ratio (RR) with 95% confidence intervals (CI). Results: The mean (SD) age of the cohort (n = 4183) was 46.3 (15.5) years; 17.9% (748/4183) had received at least one dose of CovishieldTM and 4.8% (201/4183) had received Covaxin (R). Mortality was 0.2% (95% CI: 0.2% - 0.7%), 3.5% (1.9-5.2%), 6.2% (0.3-12%) and 12.9% (11.8-14.1%) among fully vaccinated (>2 weeks after two doses), partially vaccinated (>2 weeks after one dose or <2 weeks after two doses), indeterminate (<2 weeks after one dose) and unvaccinated patients respectively. The difference in mortality among unvaccinated vs. fully vaccinated was 12.7% (95% CI: 11.4-13.9%), unvaccinated vs. partially vaccinated was 9.4% (7.4-11.4%) and unvaccinated vs. indeterminate vaccinated was 6.8% (0.8-12.7%). On adjusted analysis, as compared to unvaccinated patients, at least one dose of vaccine reduced the need for hospitalization (RR: 0.40; 95% CI: 0.35-0.47), oxygen (0.33; 0.27-0.40), NIV (0.23; 0.17-0.32), ICU admission (0.18; 0.12-0.27) and mortality (0.18; 0.11-0.29). Conclusion: Among symptomatic COVID-19 patients, prior vaccination with Covishield (TM) or Covaxin (R) impacted the severity of illness and reduced mortality during a period of widespread delta variant circulation. Full vaccination conferred greater protection than partial vaccination. (C) 2022 Elsevier Ltd. All rights reserved.

引用

页码：2107 / 2113

页数：7

共 21 条

[21] The High Mortality and Impact of Vaccination on COVID-19 in Hemodialysis Population in India During the Second Wave [J].

Yadav, Ashok K. ;

Sankarasubbaiyan, Suresh ;

Gowda, B. G. Mallikarjuna ;

Shah, Kamal ;

Jha, Vivekanand .

KIDNEY INTERNATIONAL REPORTS, 2021, 6 (10) :2731-2731

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