Crosstalk between angiogenesis and immune regulation in the tumor microenvironment

被引：46
作者：
Kim, Hei Jung [1 ]
Ji, Young Rae [2 ]
Lee, You Mie [1 ,3 ]
机构：
[1] Kyungpook Natl Univ, Vessel Organ Interact Res Ctr, VOICE MRC, 80 Daehak Ro, Daegu 41566, South Korea
[2] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD USA
[3] Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Dept Mol Pathophysiol, 80 Daehak Ro, Daegu 41566, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2022年 / 45卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Tumor microenvironment; Angiogenesis; Immune suppressive tumor; Tumor-associated macrophage; Treg cells; ENDOTHELIAL GROWTH-FACTOR; CD8(+) T-CELLS; HYPOXIA-INDUCIBLE FACTORS; NATURAL-KILLER-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; NK CELLS; B-CELLS; PERIPHERAL-BLOOD; VESSEL NORMALIZATION;
D O I：
10.1007/s12272-022-01389-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer creates a complex tumor microenvironment (TME) composed of immune cells, stromal cells, blood vessels, and various other cellular and extracellular elements. It is essential for the development of anti-cancer combination therapies to understand and overcome this high heterogeneity and complexity as well as the dynamic interactions between them within the TME. Recent treatment strategies incorporating immune-checkpoint inhibitors and anti-angiogenic agents have brought many changes and advances in clinical cancer treatment. However, there are still challenges for immune suppressive tumors, which are characterized by a lack of T cell infiltration and treatment resistance. In this review, we will investigate the crosstalk between immunity and angiogenesis in the TME. In addition, we will look at strategies designed to enhance anti-cancer immunity, to convert "immune suppressive tumors" into "immune activating tumors," and the mechanisms by which these strategies enhance effector immune cell infiltration.
引用
收藏
页码：401 / 416
页数：16
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