Silylstannylation of highly functionalized acetylenes. Synthesis of precursors for annulations via radical or Heck reactions

被引：25

作者：

Apte, S ^{[1
]}

Radetich, B ^{[1
]}

Shin, S ^{[1
]}

Rajanbabu, TV ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol048265w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd-catalyzed silylstannylation of acetylenes tolerates a variety of reactive functional groups (aldehydes, nonterminal acetylenes, epoxides, activated and unactivated olefins), providing easy access to precursors that can be converted into carbocyclic and heterocyclic compounds via free radical or Heck reactions. Examples of the synthesis of pyrrolidines, bicyclic beta-lactams, hydrindanes, and tetrahydrofurans are described.

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页码：4053 / 4056

页数：4

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