In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

被引：10
作者：
Ghorab, Mostafa M. [1 ,2 ]
Alsaid, Mansour S. [1 ]
Al-Dosari, Mohammed S. [1 ]
El-Gazzar, Marwa G. [2 ]
Arbab, Ahmed H. [1 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, POB 2457, Riyadh 11451, Saudi Arabia
[2] EAEA, NCRRT, Dept Drug Radiat Res, Cairo 113701, Egypt
来源：
MOLECULES | 2016年 / 21卷 / 04期
关键词：
synthesis; sulfonamides; thioureido; anticancer activity; CARBONIC-ANHYDRASE INHIBITORS; RADIOSENSITIZING EVALUATION; SULFONAMIDES; DESIGN;
D O I：
10.3390/molecules21040409
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.
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页数：8
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