A Facile and Efficient Synthesis of Spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] Derivatives via Microwave-assisted Multicomponent Reactions

被引：12
作者：
Wang, Jing [1 ]
Li, Jie [1 ]
Liu, Hongzhi [1 ]
Xu, Zhou [1 ]
Zhu, Songlei [1 ,2 ]
机构：
[1] Xuzhou Med Coll, Sch Pharm, Dept Chem, Xuzhou 221004, Jiangsu, Peoples R China
[2] Jiangsu Normal Univ, Key Lab Green Synth Funct Mat Jiangsu Prov, Xuzhou 221009, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2015年 / 12卷 / 01期
关键词：
spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine; microwave; multicomponent reactions; ONE-POT SYNTHESIS; SPIROOXINDOLES; HETEROCYCLES; MOLECULES; ISATINS; DESIGN; WATER;
D O I：
10.2174/157017861201150112124526
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient synthesis of spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] derivatives by one-pot reactions of isatins, 2,6-diaminopyrimidin-4-one or 6-aminopyrimidine-2,4-dione and malononitrile under microwave irradiation conditions was investigated. This protocol has the virtue of short reaction time, high yields and easy work-up procedure.
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收藏
页码：62 / 66
页数：5
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