Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex

被引：18

作者：

Huang, Sijie ^{[1
,2
,3
]}

Xu, Peiyu ^{[1
,2
]}

Tan, Yangxia ^{[1
,2
]}

You, Chongzhao ^{[1
,2
]}

Zhang, Yumu ^{[1
,2
,3
]}

Jiang, Yi ^{[1
,2
]}

Xu, H. Eric ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China

来源：

CELL RESEARCH | 2021年 / 31卷 / 09期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1038/s41422-021-00527-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1036 / 1038

页数：3

共 10 条

[1] Lasmiditan mechanism of action - review of a selective 5-HT1Fagonist [J].

Clemow, David B. ;

Johnson, Kirk W. ;

Hochstetler, Helen M. ;

Ossipov, Michael H. ;

Hake, Ann M. ;

Blumenfeld, Andrew M. .

JOURNAL OF HEADACHE AND PAIN, 2020, 21 (01)

[2] Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go [J].

Garcia-Nafria, Javier ;

Nehme, Rony ;

Edwards, Patricia C. ;

Tate, Christopher G. .

NATURE, 2018, 558 (7711) :620-+

[3] Structure and function of serotonin G protein-coupled receptors [J].

McCorvy, John D. ;

Roth, Bryan L. .

PHARMACOLOGY & THERAPEUTICS, 2015, 150 :129-142

[4] What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands? [J].

Michino, Mayako ;

Beuming, Thijs ;

Donthamsetti, Prashant ;

Newman, Amy Hauck ;

Javitch, Jonathan A. ;

Shi, Lei .

PHARMACOLOGICAL REVIEWS, 2015, 67 (01) :198-213

[5] Serotonin receptor agonists in the acute treatment of migraine: a review on their therapeutic potential [J].

Negro, Andrea ;

Koverech, Angela ;

Martelletti, Paolo .

JOURNAL OF PAIN RESEARCH, 2018, 11 :515-526

[6] Preclinical pharmacological profile of the selective 5-HTIF receptor agonist lasmiditan [J].

Nelson, David L. ;

Phebus, Lee A. ;

Johnson, Kirk W. ;

Wainscott, David B. ;

Cohen, Marlene L. ;

Calligaro, David O. ;

Xu, Yao-Chang .

CEPHALALGIA, 2010, 30 (10) :1159-1169

[7] Serotonin Receptors - From Molecular Biology to Clinical Applications [J].

Pytliak, M. ;

Vargova, V. ;

Mechirova, V. ;

Felsoeci, M. .

PHYSIOLOGICAL RESEARCH, 2011, 60 (01) :15-25

[8] Triptans and troponin: a case report [J].

Weder, Claudia R. ;

Schneemann, Markus .

ORPHANET JOURNAL OF RARE DISEASES, 2009, 4

[9] Structural insights into the lipid and ligand regulation of serotonin receptors [J].

Xu, Peiyu ;

Huang, Sijie ;

Zhang, Huibing ;

Mao, Chunyou ;

Zhou, X. Edward ;

Cheng, Xi ;

Simon, Icaro A. ;

Shen, Dan-Dan ;

Yen, Hsin-Yung ;

Robinson, Carol, V ;

Harpsoe, Kasper ;

Svensson, Bo ;

Guo, Jia ;

Jiang, Hualiang ;

Gloriam, David E. ;

Melcher, Karsten ;

Jiang, Yi ;

Zhang, Yan ;

Xu, H. Eric .

NATURE, 2021, 592 (7854) :469-+

[10] Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist [J].

Yin, Wanchao ;

Zhou, X. Edward ;

Yang, Dehua ;

de Waal, Parker W. ;

Wang, Meitian ;

Dai, Antao ;

Cai, Xiaoqing ;

Huang, Chia-Ying ;

Liu, Ping ;

Wang, Xiaoxi ;

Yin, Yanting ;

Liu, Bo ;

Zhou, Yu ;

Wang, Jiang ;

Liu, Hong ;

Caffrey, Martin ;

Melcher, Karsten ;

Xu, Yechun ;

Wang, Ming-Wei ;

Xu, H. Eric ;

Jiang, Yi .

CELL DISCOVERY, 2018, 4

← 1 →