Enantioselective approach to the synthesis of cyclohexane carbocyclic nucleosides

被引：31
作者：
Wang, J
Busson, R
Blaton, N
Rozenski, J
Herdewijn, P
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium
[2] Fac Pharmaceut Sci, B-3000 Louvain, Belgium
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 09期
关键词：
D O I：
10.1021/jo972285c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(R)-(-)-Carvone was used as starting material for the synthesis of a new series of 2-(hydroxymethyl)cyclohexane-1,3-diol nucleosides. The enantioselective precursors of the nucleoside analogues were obtained via a stereo-and regioselective hydroboration reaction. The compounds have equatorial oriented base moieties despite the presence of three other axial substituents.
引用
收藏
页码：3051 / 3058
页数：8
相关论文
共 37 条
1234