Positive and negative selection of T cells

被引：1144
作者：
Starr, TK [1 ]
Jameson, SC
Hogquist, KA
机构：
[1] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
来源：
ANNUAL REVIEW OF IMMUNOLOGY | 2003年 / 21卷
关键词：
T cell development; thymocyte; thymus; allelic exclusion; differential signaling;
D O I：
10.1146/annurev.immunol.21.120601.141107
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection and discuss a model for how these disparate outcomes can be signaled via the same receptor. We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated.
引用
收藏
页码：139 / 176
页数：38
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